Effects of deprenyl on monoamine oxidase and neurotransmitters in the brains of MPTP-treated aging mice.
Effects of deprenyl on monoamine oxidase and neurotransmitters in the brains of MPTP-treated aging mice.
复制标题
丙炔苯丙胺对 MPTP 治疗的衰老小鼠大脑中单胺氧化酶和神经递质的影响。
DOI：
10.1007/bf00973091
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发表时间：
1995
影响因子：
4.4
通讯作者：
Wiener,HL
中科院分区：
文献类型：
--
作者：
Gupta,M;Wiener,HL
丙炔苯丙胺是一种选择性单胺氧化酶B（MAO-B）抑制剂，已用于治疗帕金森病。然而，尚不清楚丙炔苯丙胺的作用是症状性的还是药理性的。用MPTP部分损伤衰老小鼠。对照组和MPTP治疗组小鼠在饮用水中给予丙炔苯丙胺14天。脑组织（包括纹状体、嗅结节和大脑皮质）测定MAO-B和神经递质水平。结果表明，丙炔苯丙胺处理，单独或MPTP后，降低MAO-B活性在所有三个区域。多巴胺（DA），3，4-二羟基苯乙酸（DO-PAC），高香草酸（HVA）含量在任何三个领域没有变化。皮质去甲肾上腺素（NE）水平也未改变。然而，纹状体5-羟色胺（5-HT）水平下降，而其代谢产物，5-HIAA水平显着增加，在动物接受丙炔苯丙胺单独的嗅结节。这些数据表明，丙炔苯丙胺治疗降低MAO-B活性的区域，除了纹状体，而不影响去甲肾上腺素，多巴胺（DA）及其代谢产物。
Deprenyl is a selective monoamine oxidase B (MAO-B) inhibitor and has been used in the treatment of Parkinson's disease. However, it is not known whether deprenyl effects are symptomatic or pharmacological. Aging mice were partially lesioned with MPTP. Control and MPTP-treated mice were given deprenyl in drinking water for 14 days. Brain tissue (including the striatum, olfactory tubercle and cerebral cortex) was assayed for MAO-B and neurotransmitter levels. The results show that deprenyl treatment, given alone or after MPTP, reduced MAO-B activity in all the three regions. No change was seen in dopamine (DA), 3,4-dihydroxyphenyl acetic acid (DO-PAC), and homovanillic acid (HVA) content in any of the three areas. Cortical norepinephrine (NE) levels were also unaltered. However, striatal serotonin (5-HT) levels were decreased while its metabolite, 5-HIAA levels were significantly increased in the olfactory tubercle in animals receiving deprenyl alone. These data suggest that deprenyl treatment reduces MAO-B activity in regions in addition to the striatum without affecting norepinephrine, dopamine (DA) and its metabolites.