The β-adrenoceptors in the smooth muscle of pig coronary arteries
The β-adrenoceptors in the smooth muscle of pig coronary arteries
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猪冠状动脉平滑肌中的β-肾上腺素能受体
DOI：
10.1016/0014-2999(73)90075-7
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发表时间：
1973
影响因子：
5
通讯作者：
B. Johansson
中科院分区：
文献类型：
--
作者：
B. Johansson
本文通过研究三种不同的β受体阻滞剂对异丙肾上腺素引起的猪冠状动脉条舒张反应的影响，试图将冠状动脉血管β受体分为β_1和β_2。该研究包括普萘洛尔作为心脏和外周血管β-肾上腺素受体的强效阻滞剂，H 93/26，1-异丙基氨基-3-[4-（2-甲氧基乙基）-苯氧基]-2-丙醇，作为“心脏选择性”β-阻滞剂，和H 35/25，2-异丙基氨基-1-（4-甲基苯基）-1-丙醇，作为对外周肾上腺素受体具有主要作用的阻滞剂。后两种物质的不同影响通过对离体大鼠心房和大鼠门静脉的实验来说明。冠状动脉条对所有3种阻滞剂的敏感性类似于心房效应器，但与静脉平滑肌不同。提示冠状动脉β-肾上腺素能受体应归为β_1型。
An attempt has been made to classify the coronary vascular β-adrenoceptors as ‘β1’ or ‘β2’ by studying the effect of 3 different β-blocking agents on the isoprenaline-induced relaxation of isolated strips of pig coronary arteries. The study includes propranolol as a potent blocker of both cardiac and peripheral vascular β-adrenoceptors, H 93/26, 1-isopropylamino-3-[4-(2-methoxyethyl)-phenoxyl]-2-propanol, as a ‘cardioselective’ β-blocker, and H 35/25, 2-isopropylamino-1-(4-methylphenyl)- 1-propanol, as a blocker with predominant action on the peripheral adrenoceptors. The differential influence of the latter 2 substances is illustrated by experiments on isolated rat atria and rat portal veins. The coronary artery strips resembled the atrial effectors in their sensitivity to all 3 blockers but they differed from the venous smooth muscle. It is suggested that the β-adrenoceptors of the coronary arteries should be placed in the β1category.