Reaction tubes: A new platform for silicon nanophotonic ring resonator sensors
Reaction tubes: A new platform for silicon nanophotonic ring resonator sensors
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DOI：
10.1063/1.4863782
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发表时间：
2014-01-28
影响因子：
3.2
通讯作者：
Bienstman, P.
中科院分区：
文献类型：
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作者：
Arce, C. Lerma;Van Put, S.;Bienstman, P.
与其他标记和无标记传感技术相比，硅纳米光子环形谐振器传感器的无标记生物传感已被证明是一种出色的传感技术，可实现高通量和高灵敏度。然而，与任何生物传感平台一样，硅纳米光子环形谐振器传感器需要允许将样品连续递送到传感器表面的流体组件。这是该平台的最大缺点，因为这种类型的微流体系统在日常实践中被去除得很远，例如。例如，在一个实施例中，医院实验室，在很大程度上仍然依赖于96孔微量滴定板或反应管等平台。为了解决这一主要缺点，我们提出了一个简单的和实验室兼容的反应管平台的组合，与无标记的纳米光子生物传感器与嵌入到同一芯片中的特殊微流体系统，其中的流动是通过芯片，而不是在芯片上更传统的方法。这表明，无标记纳米光子环形谐振器也可以用于用户友好的平台，如反应管或微孔板，保持其优异的性能。(C)2014 AIP Publishing LLC.
Label-free biosensing with silicon nanophotonic ring resonator sensors has proven to be an excellent sensing technique for achieving high throughput and high sensitivity, comparing favorably with other labeled and label-free sensing techniques. However, as in any biosensing platform, silicon nanophotonic ring resonator sensors require a fluidic component that allows the continuous delivery of the sample to the sensor surface. This is the big disadvantage of this platform since this type of microfluidic system is very much removed from the daily practice in, e. g., hospital labs, which still relies to a large degree on platforms like 96-well microtiter plates or reaction tubes. To address this major drawback, we propose the combination of a simple and lab-compatible reaction tube platform, with label-free nanophotonic biosensors with a special microfluidic system imbedded into the same chip, where the flow is through the chip rather than over the chip as in more traditional approaches. This shows that label-free nanophotonic ring resonators can be also used in the user-friendly platform like reaction tubes or well microtiter plates, conserving their excellent performance. (C) 2014 AIP Publishing LLC.