PET and SPECT of Neurobiological Systems
PET and SPECT of Neurobiological Systems
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DOI：
10.2967/jnumed.115.164616
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Hongyoon Choi;D. Lee
中科院分区：
文献类型：
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作者：
Hongyoon Choi;D. Lee
强度可以反映微血管损伤，从而解释痴呆或认知障碍。读者还可以了解阿尔茨海默病的脑血管风险因素，以及血管和退行性过程对患者痴呆症的不同贡献这一诱人的话题。读者将被引导思考这个话题的敏感性，因为阿尔茨海默病和皮质下血管性痴呆之间的模糊界限。我们可以改进本书中介绍的PET和SPECT研究，以用于区分或表征各种疾病。介绍了几种类型的受体PET，包括烟碱乙酰胆碱受体系统和痴呆症炎症的成像。考虑到炎症在神经退行性疾病和神经精神疾病中的重要性，强调小胶质细胞活化的神经炎症PET是适当的。然而，在另一章中，使用不同名称的转运蛋白PET/SPECT来描述多发性硬化症的相同技术是令人讨厌的。相比之下，在2章中分别处理炎症和动脉粥样硬化的颈动脉成像的决定是有吸引力的。这本书涵盖了临床上最常见的颈动脉脆弱性成像的研究-18F-FDG PET-以及介绍脂质积累的实验或临床前成像，血栓形成的成像和与颈动脉粥样硬化斑块相关的血管生成成像。这些话题似乎足以吸引医生的兴趣。癫痫研究在这本书集中在新的PET配体显示g-氨基丁酸能传输，多巴胺能或阿片类药物传输，和P-糖蛋白1。所列的功能PET研究在揭示癫痫的病理生理学方面有着有趣的发现，并有望在抗癫痫药物的开发中使用PET和SPECT。
intensity that can reflect microvascular injuries and thus explain dementia or cognitive impairment. Readers are also presented with the cerebrovascular risk factors for Alzheimer disease, as well as the tantalizing topic of the differential contribution of vascular and degenerative processes to a patient’s dementia. Readers will be led to ponder the sensitivity of this topic because of the fuzzy boundary between Alzheimer disease and subcortical vascular dementia. We might refine the PET and SPECT studies introduced in this book for possible use in discriminating or characterizing various conditions. A few types of receptor PET are introduced, including imaging of the nicotinic acetylcholine receptor system and of inflammation in dementia. Considering the importance of inflammation in neurodegenerative and neuropsychiatric illnesses, the emphasis on neuroinflammation PET of microglial activation is appropriate. However, in another chapter, use of the different name of translocator protein PET/SPECT to describe the same technique for multiple sclerosis is annoying. In contrast, the decision to deal with carotid artery imaging of inflammation and atherosclerosis separately in 2 chapters is appealing. The book covers the most common study for imaging of carotid vulnerability in the clinic—18F-FDG PET—as well as introducing experimental or preclinical imaging of lipid accumulation, imaging of thrombosis, and angiogenesis imaging related to carotid atherosclerotic plaque. These topics seem sufficient to attract physicians’ interest. The epilepsy studies in this book focus on novel PET ligands showing g-aminobutyric acid–ergic transmission, serotonergic or opioid transmission, and P-glycoprotein 1. The listed functional PET studies have interesting findings in disclosing the pathophysiology of epilepsy and promise the future use of PET and SPECT in the development of antiepileptic drugs.