POLYADENYLIC ACID SEQUENCES - ROLE IN CONVERSION OF NUCLEAR RNA INTO MESSENGER RNA
POLYADENYLIC ACID SEQUENCES - ROLE IN CONVERSION OF NUCLEAR RNA INTO MESSENGER RNA
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DOI：
10.1126/science.174.4008.507
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发表时间：
1971-01-01
期刊：
影响因子：
56.9
通讯作者：
ADESNIK, M
中科院分区：
文献类型：
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作者：
DARNELL, JE;PHILIPSON, L;ADESNIK, M
在真核细胞中，含有150至250个核苷酸的聚腺苷酸[poly（A）]片段似乎与异质核RNA（HnRNA）和信使RNA（mRNA）共价连接。poly（A）在细胞核中合成，并且可能最初与HnRNA连接，HnRNA最终作为mRNA转运到细胞质。RNA或poly（A）合成抑制剂的研究表明poly（A）片段的合成不依赖于转录。poly（A）标记物可能被证明有助于阐明真核细胞中的mRNA修饰和转运。
Polyadenylic acid [poly(A)] segments containing 150 to 250 nucleotides appear to be covalently linked to heterogeneous nuclear RNA (HnRNA) and messenger RNA (mRNA) in eucaryotic cells. The poly(A) is synthesized in the nucleus, and is probably linked initially to HnRNA that is ultimately transported as mRNA to the cytoplasm. Studies with inhibitors of RNA or poly(A) synthesis indicate that synthesis of poly(A) segments is independent of transcription. The poly(A) marker may prove useful to elucidate mRNA modification and transport in eucaryotic cells.