Utility of semiquantitative parameters to differentiate benign and malignant focal hepatic lesions
Utility of semiquantitative parameters to differentiate benign and malignant focal hepatic lesions
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DOI：
10.1016/j.clinimag.2013.01.012
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发表时间：
2013-07-01
期刊：
影响因子：
2.1
通讯作者：
Comunoglu, Cem
中科院分区：
文献类型：
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作者：
Alicioglu, Banu;Guler, OmerTolga;Comunoglu, Cem
目的：前瞻性研究了血管瘤、肝细胞癌（HCC）和肝转移瘤中使用细胞外钆对比剂获得的动态对比增强（DCE）MRI的半定量参数的任何区别和有用性。方法：37例患者的74个肝脏局灶性病变（包括34个血管瘤，23个HCC和17个转移瘤）进行了DCE-MRI（6个期）。使用FuncTool获得功能彩色图和随后的半定量参数。通过放置感兴趣区，测量平均增强时间（MTE）、阳性增强积分（PEI）、达峰时间（TP）、最大增加斜率（MSI）、最大减少斜率（MSD）的最大值和平均值。HCC和转移灶的诊断均经组织病理学和/或临床证实。结果如下：参数的平均值为：在血管瘤中，avgMTE：271.2 ± 4.7; avgPEI：840.3 ± 77.3; avgTP：146.6 ± 13.1; avgMSI：999.1 ± 108.4; avgMSD：254.1 ± 30.4。在HCC中，平均MTE：246 +/-3.6;平均PEI：424.9 +/-31.6;平均TP：132.8 +/-9.5;平均MSI：484.1 +/-36.5;平均MSD：109.1 +/-133。在转移瘤中，平均MTE：248.1 +/-82，平均PEI：453.9 +/-39.6;平均TP：142.8 +/-13.9;平均MSI：472.6 +/-50.4和平均MSD：200.1 +/-38.2。血管瘤的MTE、PEI、MSI和MSD的最大值和平均值均显著较高（P.05）。结论：半定量DCE-MRI参数提供了有用的、互补的和定量的信息。该技术增加了细胞外钆造影剂的诊断价值，以表征局灶性肝脏病变，并可能有助于局部区域治疗后的随访。(c)2013 Elsevier Inc. All rights reserved.
Objective: Any distinction and the usefulness of semiquantitative parameters derived from dynamic-contrast-enhanced (DCE) MRI obtained with extracellular gadolinium contrast agent in hemangiomas, hepatocellular carcinomas (HCC) and metastases of the liver was studied prospectively. Methods: Seventy-four focal liver lesions (consisted of 34 hemangiomas, 23 HCC, and 17 metastases) of the 37 patients underwent DCE-MRI (six phases). Functional coloured maps and subsequently semiquantitative parameters were obtained using the FuncTool. Maximum and average (avg) values of mean time to enhancement (MTE), positive enhancement integral (PEI), time to peak (TP), maximum slope of increase (MSI), maximum slope of decrease (MSD) values were measured by placing the region of interest. The diagnosis of HCC and metastases were proven histopathologically and/or clinically. Results: The mean values of the paremeters were: In hemangiomas, avgMTE: 271.2 +/- 4.7; avgPEI: 840.3 +/- 77.3; avgTP: 146.6 +/- 13.1; avgMSI: 999.1 +/- 108.4; avgMSD: 254.1 +/- 30.4. In HCC, avgMTE: 246 +/- 3.6; avgPEI: 424.9 +/- 31.6; avgTP: 132.8 +/- 9.5; avgMSI: 484.1 +/- 36.5; avgMSD: 109.1 +/- 133. In metastases, avgMTE: 248.1 +/- 82, avgPEI: 453.9 +/- 39.6; avgTP: 142.8 +/- 13.9; avgMSI: 472.6 +/- 50.4 and avg MSD: 200.1 +/- 38.2. Both maximum and avg values of MTE, PEI, MSI, and MSD were significantly higher in hemangiomas (P.05). Conclusions: Semiquantitative DCE-MRI parameters provide useful, complementary, and quantitative information. This technique increases diagnostic value of extracellular gadolinium contrast agent to characterize focal liver lesions and may be useful for follow-up after local-regional therapies. (c) 2013 Elsevier Inc. All rights reserved.