Transforming growth factor β signaling in uterine development and function.

Transforming growth factor β signaling in uterine development and function.
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DOI:
10.1186/2049-1891-5-52
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发表时间:
2014
影响因子:
7
通讯作者:
Li Q
Li Q
中科院分区:
农林科学1区
文献类型:
--
作者:
Li Q

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转化生长因子β超家族在进化上是保守的,在细胞的生长和分化中起着重要作用。越来越多的证据支持它在女性生殖和发育中的重要作用。转化生长因子受体1-3是该生长因子家族的创始成员,然而,转化生长因子β信号在子宫中的体内功能仍不清楚。本文以小鼠和人类的研究为主要来源,重点介绍了转化生长因子β在子宫中信号转导的最新研究进展。该综述还考虑了转化生长因子β信号失控在导致妇女妊娠丢失和生育问题的病理条件中的作用。
Transforming growth factor β (TGFβ) superfamily is evolutionarily conserved and plays fundamental roles in cell growth and differentiation. Mounting evidence supports its important role in female reproduction and development. TGFBs1-3 are founding members of this growth factor family, however, the in vivo function of TGFβ signaling in the uterus remains poorly defined. By drawing on mouse and human studies as a main source, this review focuses on the recent progress on understanding TGFβ signaling in the uterus. The review also considers the involvement of dysregulated TGFβ signaling in pathological conditions that cause pregnancy loss and fertility problems in women.
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