Epigallocatechin-3-gallate (EGCG): Chemical and biomedical perspectives
Epigallocatechin-3-gallate (EGCG): Chemical and biomedical perspectives
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DOI：
10.1016/j.phytochem.2006.06.020
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发表时间：
2006-09-01
期刊：
影响因子：
3.8
通讯作者：
Zhou, Yu-Dong
中科院分区：
文献类型：
--
作者：
Nagle, Dale G.;Ferreira, Daneel;Zhou, Yu-Dong
化合物（-）-表没食子儿茶素-3-没食子酸酯（EGCG）是在绿色茶[Camellia sinensis L. Ktze（Theaceae）]。这种多酚化合物和几种相关的儿茶素被认为是负责与消费绿色茶相关的健康益处。绿色茶和EGCG的潜在健康益处包括抗氧化作用，癌症化学预防，改善心血管健康，增强减肥，保护皮肤免受电离辐射造成的损害等。化合物EGCG已被证明可以调节数十种疾病特异性分子靶点。这些分子靶点中的许多仅受远远高于通过饮用绿色茶或消耗中等剂量的基于绿色茶提取物的膳食补充剂所达到的水平的EGCG浓度的影响。尽管如此，最近设计良好的双盲对照临床研究已经证明了绿色茶提取物和纯化的EGCG产品在患者中的功效。因此，本文综述了作者认为最近一些最具临床意义的研究结果，并介绍了EGCG立体选择性全合成的最新进展。(c)2006爱思唯尔有限公司保留所有权利。
The compound (-)-epigallocatechin-3-gallate (EGCG) is the major catechin found in green tea [Camellia sinensis L. Ktze. (Theaceae)]. This polyphenolic compound and several related catechins are believed to be responsible for the health benefits associated with the consumption of green tea. The potential health benefits ascribed to green tea and EGCG include antioxidant effects, cancer chemoprevention, improving cardiovascular health, enhancing weight loss, protecting the skin from the damage caused by ionizing radiation, and others. The compound EGCG has been shown to regulate dozens of disease-specific molecular targets. Many of these molecular targets are only affected by concentrations of EGCG that are far above the levels achieved by either drinking green tea or consuming moderate doses of green tea extract-based dietary supplements. In spite of this, well-designed double-blinded controlled clinical studies have recently demonstrated the efficacy of green tea extracts and purified EGCG products in patients. Therefore, this review highlights results from what the authors believe to be some of the most clinically significant recent studies and describes current developments in the stereoselective total synthesis of EGCG. (c) 2006 Elsevier Ltd. All rights reserved.