fw2.2:: A quantitative trait locus key to the evolution of tomato fruit size
fw2.2:: A quantitative trait locus key to the evolution of tomato fruit size
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DOI：
10.1126/science.289.5476.85
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发表时间：
2000-07-07
期刊：
影响因子：
56.9
通讯作者：
Tanksley, SD
中科院分区：
文献类型：
--
作者：
Frary, A;Nesbitt, TC;Tanksley, SD
许多植物的驯化与果实大小的急剧增加有关。在番茄中，一个数量性状基因座 (QTL) fw2.2 负责这一过程中的一大步。当转化为大果品种时，源自小果野生物种的 fw2.2 区域的粘粒使果实大小减少了预期的量，并具有 fw2.2 预期的基因作用。 QTL 效应的原因是单个基因 ORFX，该基因在花发育早期表达，控制心皮细胞数量，并且具有与人类癌基因 c-H-ras p21 结构相似的序列。 fw2.2 等位基因引起的果实大小的改变很可能是由于调节的变化而不是编码蛋白质的序列和结构的变化。
Domestication of many plants has correlated with dramatic increases in fruit size. In tomato, one quantitative trait Locus (QTL), fw2.2, was responsible for a Large step in this process. When transformed into large-fruited cultivars, a cosmid derived from the fw2.2 region of a small-fruited wild species reduced fruit size by the predicted amount and had the gene action expected for fw2.2. The cause of the QTL effect is a single gene, ORFX, that is expressed early in floral development, controls carpel cell number, and has a sequence suggesting structural similarity to the human oncogene c-H-ras p21. Alterations in fruit size, imparted by fw2.2 alleles, are most Likely due to changes in regulation rather than in the sequence and structure of the encoded protein.