Rhythmic control of activity and sleep by class B1 GPCRs.
Rhythmic control of activity and sleep by class B1 GPCRs.
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DOI：
10.3109/10409238.2014.985815
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发表时间：
2015-01
影响因子：
6.5
通讯作者：
Nitabach MN
中科院分区：
文献类型：
--
作者：
Kunst M;Tso MC;Ghosh DD;Herzog ED;Nitabach MN
B1类G蛋白偶联受体(GPCRs)家族的成员，其配体是神经肽，在不同的后生动物分支中参与昼夜节律和睡眠的调节。本文讨论了B1类GPCRs，特别是哺乳动物VPAC2受体及其功能同源物PDFR在果蝇和线虫中调节觉醒和日常睡眠和觉醒节律的细胞和分子机制。在这些非常不同的遗传模式生物中，B1类细胞间信号通路在协调多个细胞和组织的唤醒和昼夜节律计时方面所发挥的细胞和分子作用有显著的相似之处。
Members of the class B1 family of G-protein coupled receptors (GPCRs) whose ligands are neuropeptides have been implicated in regulation of circadian rhythms and sleep in diverse metazoan clades. This review discusses the cellular and molecular mechanisms by which class B1 GPCRs, especially the mammalian VPAC2 receptor and its functional homologue PDFR in Drosophila and C. elegans, regulate arousal and daily rhythms of sleep and wake. There are remarkable parallels in the cellular and molecular roles played by class B1 intercellular signaling pathways in coordinating arousal and circadian timekeeping across multiple cells and tissues in these very different genetic model organisms.