Stereoselective Nucleophilic Trifluoromethylation of N-(tert-Butylsulfinyl)imines by Using Trimethyl(trifluoromethyl)silane.
Stereoselective Nucleophilic Trifluoromethylation of N-(tert-Butylsulfinyl)imines by Using Trimethyl(trifluoromethyl)silane.
复制标题
DOI：
10.1002/1521-3773(20010202)40:3
复制
发表时间：
2001-02
影响因子：
--
通讯作者：
G. Prakash;M. Mandal;G. Olah
中科院分区：
文献类型：
--
作者：
G. Prakash;M. Mandal;G. Olah
提出了一种非常普遍的反应，以高收率和高立体选择性实现了CF3向手性N-（叔丁基亚胺基）亚胺的亲核转移。四丁基二氟三苯基硅酸盐铵（TBAT）作为氟源，与芳香族、杂环族和脂肪族亚砜胺反应顺利。高立体选择性表明反应通过一个开放的过渡态进行。经颅磁刺激=三甲基硅烷基。
A very general reaction is presented to achieve the nucleophilic transfer of "CF3 " to chiral N-(tert-butylsulfinyl)imines in high yield and high stereoselectivity. Tetrabutylammonium difluorotriphenylsilicate (TBAT) functions as a fluoride source, and aromatic, heterocyclic, and aliphatic sulfinylimines react smoothly. The high stereoselectivity suggests that the reaction proceeds through an open transition state. TMS=trimethylsilyl.