Stabilization of Damaged Articular Cartilage with Hydrogel-Mediated Reinforcement and Sealing.
Stabilization of Damaged Articular Cartilage with Hydrogel-Mediated Reinforcement and Sealing.
复制标题
水凝胶介导法加固封闭损伤关节软骨的实验研究
DOI：
10.1002/adhm.202100315
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发表时间：
2021-05
影响因子：
10
通讯作者：
Mauck RL
中科院分区：
文献类型：
--
作者：
Patel JM;Loebel C;Saleh KS;Wise BC;Bonnevie ED;Miller LM;Carey JL;Burdick JA;Mauck RL
软骨损伤和随之而来的组织恶化影响了数百万患者。由于功能性透明软骨的再生仍然难以实现，稳定剩余组织和防止进一步恶化的方法将具有重要的临床实用价值和延长关节功能。有限元模拟显示，加强退变的软骨(加强)和重建表层(封闭)都需要恢复组织内的液体加压，并限制液体流动和缺损面的基质丢失。在这里，设计了一种透明质酸(HA)水凝胶系统，既能与退变的软骨交错，又能促进软骨的密封。交指强化可以恢复整体和局部细胞周围的组织力学，重建组织内内源性软骨细胞的动态平衡机械转导。这种HA疗法进一步发挥了作用，提供了化学机械信号，改善了细胞间充质干细胞/基质细胞在缺损处的附着，并引导其反应，引导局部细胞外基质沉积以“封闭”缺损区。总而言之，这些结果支持了一种创新的水凝胶疗法在治疗受损软骨方面的治疗潜力，涉及细胞和组织长度。
Cartilage injuries and subsequent tissue deterioration impact millions of patients. Since the regeneration of functional hyaline cartilage remains elusive, methods to stabilize the remaining tissue, and prevent further deterioration, would be of significant clinical utility and prolong joint function. Finite element modeling shows that fortification of the degenerate cartilage (Reinforcement) and reestablishment of a superficial zone (Sealing) are both required to restore fluid pressurization within the tissue and restrict fluid flow and matrix loss from the defect surface. Here, a hyaluronic acid (HA) hydrogel system is designed to both interdigitate with and promote the sealing of the degenerated cartilage. Interdigitating fortification restores both bulk and local pericellular tissue mechanics, reestablishing the homeostatic mechanotransduction of endogenous chondrocytes within the tissue. This HA therapy is further functionalized to present chemo mechanical cues that improve the attachment and direct the response of mesenchymal stem/stromal cells at the defect site, guiding localized extracellular matrix deposition to “seal” the defect. Together, these results support the therapeutic potential, across cell and tissue length scales, of an innovative hydrogel therapy for the treatment of damaged cartilage.
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DOI：
10.1158/1541-7786.mcr-13-0629
发表时间：
2014-10
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Kim Y;Kumar S
通讯作者：
Kumar S
影响因子：
3.9
作者：
June RK;Fyhrie DP
通讯作者：
Fyhrie DP
影响因子：
3.3
作者：
Sophia Fox AJ;Bedi A;Rodeo SA
通讯作者：
Rodeo SA
DOI：
10.1053/jars.2002.32839
发表时间：
2002-09-01
影响因子：
4.7
作者：
Hjelle, K;Solheim, E;Brittberg, M
通讯作者：
Brittberg, M
影响因子：
3.9
作者：
Bonassar, LJ;Grodzinsky, AJ;Trippel, SB
通讯作者：
Trippel, SB