Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation.

Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation.
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DOI:
10.1039/c6cc06147h
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发表时间:
2016-10-04
期刊:
Chemical communications (Cambridge, England)
影响因子:
--
通讯作者:
Chae PS
Chae PS
中科院分区:
其他
文献类型:
--
作者:
Bae HE;Mortensen JS;Ribeiro O;Du Y;Ehsan M;Kobilka BK;Loland CJ;Byrne B;Chae PS

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使用四种靶膜蛋白对一类新型去污剂(称为串联新戊二醇麦芽糖苷 (TNM))进行了评估。最好的去污剂根据目标的不同而不同,但 TNM-C12L 和 TNM-C11S 因其与 DDM 相比能够提高膜蛋白稳定性而引人注目。这些试剂具有用于膜蛋白研究的潜力。
A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.
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