Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation.
Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation.
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DOI:
10.1039/c6cc06147h
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发表时间:
2016-10-04
期刊:
影响因子:
--
通讯作者:
Chae PS
中科院分区:
文献类型:
--
作者:
Bae HE;Mortensen JS;Ribeiro O;Du Y;Ehsan M;Kobilka BK;Loland CJ;Byrne B;Chae PS
A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.
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