Diagnostic performance of central vein sign for multiple sclerosis with a simplified three-lesion algorithm.
Diagnostic performance of central vein sign for multiple sclerosis with a simplified three-lesion algorithm.
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DOI：
10.1177/1352458517726383
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Reich DS
中科院分区：
文献类型：
--
作者：
Solomon AJ;Watts R;Ontaneda D;Absinta M;Sati P;Reich DS
FLAIR* MRI上的“中央静脉征”（CVS）检测对多发性硬化（MS）具有高度特异性和敏感性。我们评估了简化CVS算法诊断MS的特异性和敏感性。评价了10名MS受试者的MRI，这些受试者没有MRI白色异常的其他合并症; 10名MS受试者和白色异常的其他合并症; 10名偏头痛、白色异常和没有其他合并症;以及10名先前被错误诊断为MS的受试者。采用3 T磁共振T2-FLAIR序列和T2* 加权序列，建立FLAIR* 图像。三名对诊断不知情的MS医师评审员评价了两种不同的算法：1）随后在FLAIR*（select 3）上评价了在FLAIR上预选的三个病变的CVS。2)使用CVS（select 3 *）对最多3处病变进行FLAIR* 评价。对于select 3，评价者对MS的平均特异性为0.98，敏感性为0.52，诊断的正确预测表明kappa=0.29。对于select 3 *，特异性为0.81，灵敏度为0.83，kappa为0.31。在3 T FLAIR* MRI上对3个白色病变的CVS进行简化测定，证明了诊断MS的良好特异性和敏感性以及中等的评分者间可靠性，随着进一步研究，可能成为临床应用的候选者。
Detection of a “central vein sign” (CVS) on FLAIR* MRI is highly specific and sensitive for multiple sclerosis (MS). We evaluated the specificity and sensitivity of simplified CVS algorithms for MS diagnosis. MRIs from 10 participants with MS without additional comorbidities for MRI white matter abnormalities; 10 with MS and additional comorbidities for white matter abnormalities; 10 with migraine, white matter abnormalities, and no additional comorbidities; and 10 who had previously been erroneously diagnosed with MS were evaluated. 3T MRI T2-FLAIR and T2*-weighted sequences were acquired to create FLAIR* images. Three MS physician reviewers, blinded to diagnosis, evaluated two different algorithms: 1) Three lesions pre-selected on FLAIR were subsequently evaluated for CVS on FLAIR*(select3). 2) FLAIR* was evaluated for up to three lesions with CVS(select3*). For select3, average specificity across reviewers for MS was 0.98 and sensitivity 0.52 and a correct prediction of diagnosis demonstrated kappa=0.29. For select3*, specificity was 0.81, sensitivity 0.83, and kappa 0.31. A simplified determination of CVS in three white matter lesions on 3T FLAIR* MRI demonstrated good specificity and sensitivity and fair inter-rater reliability for a diagnosis of MS and with further study, may be a candidate for clinical application.
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影响因子：
9.9
作者：
Lipton, R. B.;Bigal, M. E.;Stewart, W. F.
通讯作者：
Stewart, W. F.
影响因子：
2.4
作者：
Samaraweera, Amal P. R.;Clarke, Margareta A.;Evangelou, Nikos
通讯作者：
Evangelou, Nikos
影响因子：
11.2
作者：
Polman CH;Reingold SC;Banwell B;Clanet M;Cohen JA;Filippi M;Fujihara K;Havrdova E;Hutchinson M;Kappos L;Lublin FD;Montalban X;O'Connor P;Sandberg-Wollheim M;Thompson AJ;Waubant E;Weinshenker B;Wolinsky JS
通讯作者：
Wolinsky JS
影响因子：
48
作者：
Orton, Sarah-Michelle;Herrera, Blanca M.;Ebers, George C.
通讯作者：
Ebers, George C.
DOI：
10.1177/1352458515624975
发表时间：
2016-10
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
--
作者：
George IC;Sati P;Absinta M;Cortese IC;Sweeney EM;Shea CD;Reich DS
通讯作者：
Reich DS