Are individual differences in fatigue vulnerability related to baseline differences in cortical activation?
Are individual differences in fatigue vulnerability related to baseline differences in cortical activation?
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DOI：
10.1037/0735-7044.119.3.694
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发表时间：
2005-06-01
影响因子：
1.9
通讯作者：
George, MS
中科院分区：
文献类型：
--
作者：
Caldwell, JA;Mu, QW;George, MS
最近的证据表明，大脑皮层激活的潜在模式可能部分地解释了个体对睡眠剥夺影响的敏感性差异。在这里，功能磁共振成像（fMRI）被用来检查激活的军事飞行员的睡眠剥夺的脆弱性，以前被量化。一个斯滕贝格工作记忆任务（SWMT; S.斯滕贝格，1966）在13分钟的血氧水平依赖性功能磁共振成像扫描期间与对照任务交替完成。对SWMT激活体素的检查表明，作为一个群体，飞行员与耐疲劳的非飞行员比与易疲劳的非飞行员更相似。在飞行员中，皮质激活与模拟器飞行性能的疲劳脆弱性显着相关。这些初步数据表明，基线功能磁共振成像扫描激活在工作记忆任务可能与疲劳易感性。
Recent evidence suggests that underlying patterns of cortical activation may partially account for individual differences in susceptibility to the effects of sleep deprivation. Here, functional magnetic resonance imaging (fMRI) was used to examine the activation of military pilots whose sleep-deprivation vulnerability previously was quantified. A Sternberg Working Memory Task (SWMT; S. Sternberg, 1966) was completed alternately with a control task during a 13-min blood oxygen level-dependent fMRI scan. Examination of the activated voxels in response to SWMT indicated that, as a group, the pilots were more similar to fatigue-resistant nonpilots than to fatigue-vulnerable nonpilots. Within the pilots, cortical activation was significantly related to fatigue vulnerability on simulator-flight performance. These preliminary data suggest that baseline fMRI scan activation during a working memory task may correlate with fatigue susceptibility.