Functional signature of recovering cortex: dissociation of local field potentials and spiking activity in somatosensory cortices of spinal cord injured monkeys.
Functional signature of recovering cortex: dissociation of local field potentials and spiking activity in somatosensory cortices of spinal cord injured monkeys.
复制标题
恢复皮层的功能特征：脊髓损伤猴子体感皮层局部场电位的分离和尖峰活动。
DOI：
10.1016/j.expneurol.2013.08.013
复制
发表时间：
2013
影响因子：
5.3
通讯作者：
Chen,LiMin
中科院分区：
文献类型：
--
作者：
Wang,Zheng;Qi,Hui-Xin;Kaas,JonH;Roe,AnnaW;Chen,LiMin
在成年猴的高颈脊髓水平的背柱传入中断后，体感皮层神经元恢复触觉刺激的手的反应，这种重新激活与恢复的手使用。然而，目前尚不清楚是否所有的神经元反应特性恢复，以及不同的皮质区域是否以类似的方式恢复。为了解决这一问题，我们记录了神经元活动的皮质区3b和S2在成年松鼠猴周后，单侧病变的背柱。我们发现，在响应振动触觉刺激，局部场电位在所有频率范围内保持稳健。然而，在高频率（≥ 15 Hz）下，神经元峰电位活动未能跟随。我们认为，在高刺激频率下未能产生尖峰活动反映了3b区和S2区抑制和兴奋平衡的变化，并且尖峰和局部场电位的这种不匹配是恢复皮层早期阶段（<两个月）的标志。
After disruption of dorsal column afferents at high cervical spinal levels in adult monkeys, somatosensory cortical neurons recover responsiveness to tactile stimulation of the hand; this reactivation correlates with a recovery of hand use. However, it is not known if all neuronal response properties recover, and whether different cortical areas recover in a similar manner. To address this, we recorded neuronal activity in cortical area 3b and S2 in adult squirrel monkeys weeks after unilateral lesion of the dorsal columns. We found that in response to vibrotactile stimulation, local field potentials remained robust at all frequency ranges. However, neuronal spiking activity failed to follow at high frequencies (≥ 15 Hz). We suggest that the failure to generate spiking activity at high stimulus frequency reflects a changed balance of inhibition and excitation in both area 3b and S2, and that this mismatch in spiking and local field potential is a signature of an early phase of recovering cortex (< two months).