BREAKAGE OF HUMAN INTERPHASE CHROMOSOMES BY ALPHA-PARTICLES AND X-RAYS
BREAKAGE OF HUMAN INTERPHASE CHROMOSOMES BY ALPHA-PARTICLES AND X-RAYS
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DOI：
10.1080/09553008914550261
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发表时间：
1989-02-01
影响因子：
2.6
通讯作者：
GOODHEAD, DT
中科院分区：
文献类型：
--
作者：
BEDFORD, JS;GOODHEAD, DT
用早期脉络膜凝聚(PCC)技术比较了慢α粒子(3.2 MeV，128keV·m~(-1))和250kVPX射线照射非周期人二倍体成纤维细胞后染色体断裂的早期形成。对于这两种辐射，PCC断裂的产生与剂量近似线性增加。α粒子的产生系数为12.5.+-。每Gy0.6%，X光为5.8.+-。每个细胞0.2个/Gy.因此，阿尔法粒子的相对生物有效性(RBE)为2.16+-。0.13。这比报道的慢速阿尔法粒子产生染色体类型交换像差的RBE值要小。这意味着，在密集电离的阿尔法粒子径迹和来自X射线的较稀疏的电离电子径迹所产生的初始断裂中，存在空间或定性上的差异。
The technique of premature chormosome condensation (PCC) was used to compare the early formation of chromosome breaks in non-cycling HF19 human diploid fibroblasts when irradiated with slow alpha particles (3.2 MeV, 128 keV .mu.m-1) or 250 kVp X-rays. For both radiations the production of PCC breaks increased approximately linearly with dose. The production coefficient for alpha particles was 12.5 .+-. 0.6 per cent per Gy and for X-rays it was 5.8 .+-. 0.2 per cell per Gy. Hence, the relative biological effectiveness (RBE) of the alpha particles was 2.16 .+-. 0.13. This is smaller than reported values of the RBE for the production of chromosome-type exchange aberrations by slow alpha particles. This implies that there, is a difference, spatial or qualitative, in the initial breaks produced by the densely ionizing alpha particle tracks and the more sparsely ionizing electron tracks from the X-rays.