Novel protein kinase targets in vascular smooth muscle therapeutics.
Novel protein kinase targets in vascular smooth muscle therapeutics.
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DOI：
10.1016/j.coph.2017.03.003
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发表时间：
2017-04
影响因子：
4
通讯作者：
Tulis DA
中科院分区：
文献类型：
--
作者：
Tulis DA
多年来，许多信号传导因子已被确定为心血管疾病（CVD）发病机制和/或维持的机制基础。其中，环核苷酸驱动的蛋白激酶在血管平滑肌（VSM）是至关重要的。主要由环AMP依赖性和环GMP依赖性蛋白激酶组成，这些普遍存在的信号分子具有通过许多下游效应物（包括血管舒张剂刺激的磷蛋白（VASP））操作以控制异常VSM生长至CVD的能力。随着更多关于CVD的遗传、生物化学、分子和细胞组成的信息被收集，包括VSM环核苷酸依赖性蛋白激酶和VASP，通过确定更精确的治疗靶点来增强临床决策，将在精准医学方面取得进展。
Many signaling factors have been identified over the years that serve as mechanistic foundations for the pathogenesis and/or maintenance of cardiovascular disease (CVD). Of these, cyclic nucleotide-driven protein kinases in vascular smooth muscle (VSM) are of essential importance. Comprised primarily of cyclic AMP-dependent and cyclic GMP-dependent protein kinases, these ubiquitous signaling molecules have capacity to operate through numerous downstream effectors including vasodilator-stimulated phosphoprotein (VASP) to control aberrant VSM growth elemental to CVD. As more information is gathered regarding genetic, biochemical, molecular and cellular makeup of CVD including VSM cyclic nucleotide-dependent protein kinases and VASP, advances will be made in precision medicine by identifying more precise therapeutic targets to enhance clinical decision making.