Pregnancy-associated mortality due to cardiovascular disease: Impact of hypertensive disorders of pregnancy.

Pregnancy-associated mortality due to cardiovascular disease: Impact of hypertensive disorders of pregnancy.
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心血管疾病导致的妊娠相关死亡率:妊娠期高血压疾病的影响。

DOI:
10.1111/ppe.13055
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发表时间:
2024
影响因子:
2.8
通讯作者:
Ananth,CandeV
Ananth,CandeV
中科院分区:
医学3区
文献类型:
--
作者:
Lee,Rachel;Brandt,JustinS;Joseph,KS;Ananth,CandeV

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背景据报道,美国孕产妇死亡率高得惊人,并且还在不断增加,而心血管疾病(CVD)是造成此类死亡的主要原因。然而,妊娠期高血压疾病 (HDP) 对心血管死亡短期风险的影响尚不清楚。 目的 评估 HDP(慢性高血压、妊娠高血压、先兆子痫、子痫和叠加先兆子痫)与妊娠相关死亡率 (PMR)、分娩时和分娩后 1 年内的 CVD 相关原因的全因死亡率 (PMR) 之间的关系。方法我们使用全国再入院数据库(2010-2018)检查 15-54 岁女性的 PMR。国际疾病分类 9 和 10 诊断代码用于识别 HDP 和 CVD 引起的妊娠相关死亡。使用离散时间 Cox 比例风险回归模型计算与 HDP 相关的分娩时(0 天)和产后 <30、<60、<90、<180 和 <365 天死亡率的调整风险比 (HR) 和 95% 置信区间 (CI)。结果在 33,417,736 例医院分娩中,HDP 发生率为 11.0% (n= 3,688,967),CVD 引起的 PMR 为每 100,000 例分娩住院中有 6.4 例 (n= 2141)。与血压正常的患者相比,CVD 相关 PMR 的 HR 随 HDP 严重程度而增加,子痫患者达到 58 倍以上。在所有 HDP 中,中风相关死亡率(1.2 至 170.9)的 HR 均高于心脏病 (HD) 相关死亡率(0.99 至 39.8)。除妊娠期高血压外,所有 HDP 的 CVD 死亡风险在分娩时和产后 1 年内均明显增加。结论 HDP 是分娩时和产后 1 年内因 CVD 导致的妊娠相关死亡的强烈危险因素;中风的风险比 HD 相关的 PMR 更高。虽然绝对 PMR 较低,但这项研究支持了对于妊娠合并高血压的患者,将产后护理扩展到传统的 42 天产后访视之外的重要性。
BackgroundReported rates of maternal mortality in the United States have been staggeringly high and increasing, and cardiovascular disease (CVD) is a chief contributor to such deaths. However, the impact of hypertensive disorders of pregnancy (HDP) on the short‐term risk of cardiovascular death is not well understood.ObjectivesTo evaluate the association between HDP (chronic hypertension, gestational hypertension, preeclampsia, eclampsia, and superimposed preeclampsia) and pregnancy‐associated mortality rates (PMR) from all causes, CVD‐related causes both at delivery and within 1 year following delivery.MethodsWe used the Nationwide Readmissions Database (2010–2018) to examine PMRs for females 15–54 years old. International Classification of Disease 9 and 10 diagnosis codes were used to identify pregnancy‐associated deaths due to HDP and CVD. Discrete‐time Cox proportional hazards regression models were used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for mortality at delivery (0 days) and at <30, <60, <90, <180, and <365 days after delivery in relation to HDP.ResultsOf 33,417,736 hospital deliveries, the rate of HDP was 11.0% (n= 3,688,967), and the PMR from CVD was 6.4 per 100,000 delivery hospitalisations (n= 2141). Compared with normotensive patients, HRs for CVD‐related PMRs increased with HDP severity, reaching over 58‐fold for eclampsia patients. HRs were higher for stroke‐related (1.2 to 170.9) than heart disease (HD)‐related (0.99 to 39.8) mortality across all HDPs. Except for gestational hypertension, the increased risks of CVD mortality were evident at delivery and persisted 1 year postpartum for all HDPs.ConclusionsHDPs are strong risk factors for pregnancy‐associated mortality due to CVD at delivery and within 1 year postpartum; the risks are stronger for stroke than HD‐related PMR. While absolute PMRs are low, this study supports the importance of extending postpartum care beyond the traditional 42‐day postpartum visit for people whose pregnancies are complicated by hypertension.
怀孕复选框和错误分类对 1999-2017 年美国孕产妇死亡率趋势的影响。
DOI: --
发表时间: 2020
期刊: Vital & health statistics. Series 3, Analytical and epidemiological studies
影响因子: --
作者:
L. Rossen;Lindsay S. Womack;D. Hoyert;Robert N. Anderson;Sayeedha F G Uddin
通讯作者: Sayeedha F G Uddin
DOI: --
发表时间: 2021
期刊:
影响因子: --
作者:
D. Hoyert
通讯作者: D. Hoyert
妊娠心脏团队降低患有心血管疾病的妇女孕产妇死亡率的潜力。
DOI: --
发表时间: 2020
影响因子: 24
作者:
P. Ouyang;Garima V Sharma
通讯作者: Garima V Sharma
DOI: 10.1016/j.nwh.2020.02.001
发表时间: 2020-04-01
影响因子: --
作者:
Vahedi, Farnoosh Asghar;Gholizadeh, Leila;Heydari, Mehrdad
通讯作者: Heydari, Mehrdad