Overview of the molecular carcinogenesis of mouse lung tumor models of human lung cancer.
Overview of the molecular carcinogenesis of mouse lung tumor models of human lung cancer.
复制标题
人肺癌小鼠肺肿瘤模型的分子致癌作用概述。
DOI：
10.1080/01926230601059993
复制
发表时间：
2007
影响因子：
1.5
通讯作者：
Sills,RobertC
中科院分区：
文献类型：
--
作者：
Wakamatsu,Nobuko;Devereux,TheodoraR;Hong,Hue-HuaL;Sills,RobertC
肺癌是全球癌症死亡的主要原因，迫切需要开发更好的诊断技术和治疗方法。小鼠模型已被用于研究人类肺癌的致癌作用，并且在人类肺癌中检测到的许多主要遗传改变也已在小鼠肺肿瘤中被鉴定。小鼠模型对于了解人类肺癌的致癌过程以及开发早期诊断技术、预防措施和治疗方法的重要性怎么强调都不过分。在这份报告中，主要已知的分子改变，在肺肿瘤的小鼠进行了审查，并与那些在人类。
Lung cancer is the leading cause of cancer death worldwide, and the need to develop better diagnostic techniques and therapies is urgent. Mouse models have been utilized for studying carcinogenesis of human lung cancers, and many of the major genetic alterations detected in human lung cancers have also been identified in mouse lung tumors. The importance of mouse models for understanding human lung carcinogenic processes and in developing early diagnostic techniques, preventive measures and therapies cannot be overstated. In this report, the major known molecular alterations in lung tumorigenesis of mice are reviewed and compared to those in humans.