Prevalence of the metabolic syndrome and its relation to cardiovascular disease in an elderly Chinese population
Prevalence of the metabolic syndrome and its relation to cardiovascular disease in an elderly Chinese population
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DOI：
10.1016/j.jacc.2005.11.074
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发表时间：
2006-04-18
影响因子：
24
通讯作者：
Hu, FB
中科院分区：
文献类型：
--
作者：
He, Y;Jiang, B;Hu, FB
本研究旨在评估中国老年人代谢综合征（MetS）的患病率及其与心血管疾病（CVD）的关系。背景基于国家胆固醇教育计划（NCEP）和国际糖尿病联合会（IDF）的中国MetS患病率信息有限。在北京城市样本中进行了一项横断面研究，共有2，334名年龄在60至95岁之间的参与者（943名男性，1，391名女性）。结果按NCEP标准，MetS的患病率为30.5%，其中男性17.6%，女性39.2%。使用新的IDF定义，患病率显著增加至46.3%（男性34.8%，女性54.1%）。使用NCEP标准，MetS患者中CHD、卒中、PAD和CVD的比值比（OR）分别为1.43（95%置信区间[CI] 1.18 - 1.74）、1.45（95% CI 1.14 - 1.85）、1.47（95% CI 1.18 - 1.84）和1.50（95% CI 1.25 - 1.81）。使用新的IDF标准的相应OR分别为1.69（95% CI 1.40 - 2.02）、1.58（95% CI 1.26 - 2.00）、1.42（95% CI 1.14 - 1.76）和1.73（95% CI 1.46 - 2.07）。符合IDF标准但不符合NCEP标准者（n = 436，18.7%），冠心病（1.66，95%CI 1.31 ~ 2.10）和脑卒中（1.53，95%CI 1.13 ~ 2.06）的OR值显著升高。根据任一标准定义的MetS患者CHD、卒中和PAD的OR显著升高。IDF标准比NCEP标准更适合于中国人群MetS的筛查和风险评估。
OBJECTIVES This study sought to assess the prevalence of the metabolic syndrome (MetS) and its association with cardiovascular disease (CVD) in elderly Chinese people.BACKGROUND The information available about the prevalence of MetS based on the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) in China is limited.METHODS We conducted a population-based cross-sectional study in an urban Beijing sample of 2,334 participants age 60 to 95 years (943 men, 1,391 women). The CVD included diagnosed coronary heart disease (CHD), stroke, and peripheral arterial disease (PAD).RESULTS The prevalence of MetS by the NCEP criteria was 30.5% (17.6% in men, 39.2% in women). Use of the new IDF definition significantly increased the prevalence to 46.3% (34.8% in men, 54.1% in women). Odds ratios (OR) for CHD, stroke, PAD, and CVD in those with MetS using the NCEP criteria were 1.43 (95% confidence interval [CI] 1.18 to 1.74), 1.45 (95% CI 1.14 to 1.85), 1.47 (95% CI 1.18 to 1.84), and 1.50 (95% CI 1.25 to 1.81), respectively. Corresponding ORs using new IDF criteria were 1.69 (95% CI 1.40 to 2.02), 1.58 (95% Cl 1.26 to 2.00), 1.42 (95% CI 1.14 to 1.76), and 1.73 (95% CI 1.46 to 2.07), respectively. Those who met the IDF but not the NCEP criteria (n = 436, 18.7%) had significantly elevated ORs for CHD (1.66, 95% CI 1.31 to 2.10) and stroke (1.53, 95% CI 1.13 to 2.06).CONCLUSIONS The MetS is highly prevalent in elderly people in Beijing, particularly among women. Individuals with MetS defined by either criteria are at significantly elevated ORs for CHD, stroke, and PAD. The IDF criteria seem to be better suited than the NCEP criteria for screening and estimating risk of MetS in Chinese people.