Subcutaneous administration of rhIGF-I post irradiation exposure enhances hematopoietic recovery and survival in BALB/c mice.
Subcutaneous administration of rhIGF-I post irradiation exposure enhances hematopoietic recovery and survival in BALB/c mice.
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辐射暴露后皮下注射 rhIGF-I 可增强 BALB/c 小鼠的造血恢复和存活率
DOI：
10.1093/jrr/rrs029
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发表时间：
2012-07
影响因子：
2
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Chen S;Xu Y;Wang S;Shen M;Chen F;Chen M;Wang A;Cheng T;Su Y;Wang J
It is unclear how to effectively mitigate against irradiation injury. In this study, we studied the capacity of recombinant human insulin-like growth factor-I (rhIGF-I) on hematologic recovery in irradiated BALB/c mice and its possible mechanism. BALB/c mice were injected with rhIGF-I subcutaneously at a dose of 100 μg/kg twice daily for 7 days after total body irradiation. Compared with a saline control group, treatment with rhIGF-I significantly improved the survival of mice after lethal irradiation (7.5 Gy). It was found that treatment with rhIGF-I not only could increase the frequency of Sca-1+ cells in bone marrow harvested at Day 14 after irradiation, but also it could decrease the apoptosis of mononuclear cells induced by irradiation as measured by flow cytometry, suggesting that rhIGF-I may mediate its effects primarily through promoting hematopoietic stem cell/progenitor survival and protecting mononuclear cells from apoptosis after irradiation exposure. Moreover, we have found that rhIGF-I might facilitate thrombopoiesis in an indirect way. Our data demonstrated that rhIGF-I could promote overall hematopoietic recovery after ionizing radiation and reduce the mortality when administered immediately post lethal irradiation exposure.
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影响因子：
20.3
作者：
GEISSLER, K;VALENT, P;MAYER, P
通讯作者：
MAYER, P
影响因子：
2.2
作者：
Yoon, M. J.;Roser, J. F.
通讯作者：
Roser, J. F.
影响因子：
2
作者：
Day, Regina M.;Barshishat-Kupper, Michal;Landauer, Michael R.
通讯作者：
Landauer, Michael R.
影响因子：
3.7
作者：
Limesand, Kirsten H.;Said, Sherif;Anderson, Steven M.
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Anderson, Steven M.
影响因子：
3.5
作者：
Cheng, Benxu;Maffi, Shivani Kaushal;Martinez, Alex Anthony;Acosta, Yolanda P. Villarreal;Morales, Liza D.;Roberts, James L.
通讯作者：
Roberts, James L.