Dual drug release from hydrogels covalently containing polymeric micelles that possess different drug release properties
Dual drug release from hydrogels covalently containing polymeric micelles that possess different drug release properties
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DOI：
10.1016/j.colsurfb.2017.02.008
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发表时间：
2017-05-01
影响因子：
5.8
通讯作者：
Murakami, Yoshihiko
中科院分区：
文献类型：
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作者：
Murata, Mari;Uchida, Yusuke;Murakami, Yoshihiko
在本研究中，我们设计了用于双重药物释放的水凝胶：共价包含具有不同药物释放特性的聚合物胶束的水凝胶。由具有紧密堆积(即，良好缠绕)内核的聚合物胶束形成的水凝胶比由具有松散堆积结构的聚合物胶束形成的水凝胶具有更高的存储模数。此外，我们进行了释放实验和荧光观察，以评估两种化合物罗丹明B和金胺O从聚合物胶束或水凝胶中的释放情况。根据我们的结果，(1)共价包含具有不同药物释放性能的聚合物胶束的水凝胶成功地展示了这两种化合物的独立释放行为；(2)荧光显微镜可以极大地促进材料的药物释放性能的评估。(C)2017爱思唯尔B.V.保留所有权利。
In the present study, we designed hydrogels for dual drug release: the hydrogels that covalently contained the polymeric micelles that possess different drug release properties. The hydrogels that were formed from polymeric micelles possessing a tightly packed (i.e., well-entangled) inner core exhibited a higher storage modulus than the hydrogels that were formed from the polymeric micelles possessing a loosely packed structure. Furthermore, we conducted release experiments and fluorescent observations to evaluate the profiles depicting the release of two compounds, rhodamine B and auramine O, from either polymeric micelles or hydrogels. According to our results, (1) hydrogels that covalently contains polymeric micelles that possess different drug release properties successfully exhibit the independent release behaviors of the two compounds and (2) fluorescence microscopy can greatly facilitate efforts to evaluate drug release properties of materials. (C) 2017 Elsevier B.V. All rights reserved.