POTENTIATION OF ANTI AKINETIC EFFECT AFTER L-DOPA TREATMENT BY AN INHIBITOR OF MAO-B, DEPRENIL
POTENTIATION OF ANTI AKINETIC EFFECT AFTER L-DOPA TREATMENT BY AN INHIBITOR OF MAO-B, DEPRENIL
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DOI：
10.1007/bf01253131
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发表时间：
1975-01-01
影响因子：
3.3
通讯作者：
LINAUER, W
中科院分区：
文献类型：
--
作者：
BIRKMAYER, W;RIEDERER, P;LINAUER, W
单胺氧化酶（MAO）“B”抑制剂Deprenil对左旋多巴治疗后的失动作用增强已在既往接受或未接受左旋多巴治疗的帕金森病患者中得到证实。该药物的应用已通过口服、静脉注射和肌肉注射进行。当与美多巴组合时，产生优异的动力学效应。与L-多巴的联合治疗是非常有效的，当应用静脉注射或肌肉注射Deprenil是一种单胺氧化酶-B的抑制剂，其特点是不太常见的副作用。这些主要是不自主运动和意识模糊，可以通过降低Deprenil的剂量来消除。MAO的每日节律可以在人类大脑的几个区域以及在对照组中被证明是在帕金森病患者中使用或不使用L-Dopa治疗。MAO的最大活性发生在中午和下午6点之间。关于脱现象的临床和生化数据进行了讨论，因为Deprenil是一种很好的预防药物。
The potentiation of the ami akinetic effect after L-Dopa treatment by an inhibitor of monoamine oxidase (MAO) “B”, Deprenil, has been demonstrated in parkinsonian patients with or without previous L-Dopa therapy. Application of the drug has been performed orally, intravenously and intramuscularly. Excellent kinetic effects resulted when combined with Madopar. The combined treatment with L-Dopa was highly effective when applicated i.v. or i.m.Deprenil is an inhibitor of MAO-B and is characterized by less frequent side effects. These are predominantly involuntary movements and confusion, which can be eliminated by lowering the dosage of Deprenil.A daily rhythm of MAO could be demonstrated in several areas of human brains as well in a control group as in parkinsonian patients with or without L-Dopa therapy. Maximal activity of MAO occurs between noon and 6 p.m.The clinical and biochemical data are discussed regarding the off-phenomenons as Deprenil is an excellent drug for preventing these.