Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy
Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy
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DOI：
10.1007/s12291-016-0584-7
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发表时间：
2017-06-01
影响因子：
2.1
通讯作者：
Shriyan, Chitra
中科院分区：
文献类型：
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作者：
D'souza, Jyothi M. P.;Harish, Sindhu;Shriyan, Chitra
蛋白质氧化已在子痫前期得到证实，但这一发现尚未在其他妊娠期高血压疾病（HDP）中得到证实。本研究比较评价了不同HDP中缺血修饰白蛋白（IMA）和高级氧化蛋白产物（AOPP），并研究了它们与总抗氧化活性（AOA）和总硫醇的关系。与对照组相比，每个HDP患者的AOPP和IMA显著升高，AOA、总硫醇和白蛋白显著降低。在HDP组中，子痫患者在各项指标上的变化更为显著。IMA和AOPP与所有HDP患者的AOA呈负相关，仅与子痫患者的总硫醇呈负相关。本研究支持氧化应激的假设，证明了蛋白质氧化增加，抗氧化状态降低，蛋白质氧化与AOA之间存在显著负相关。促氧化剂和抗氧化剂的失衡在子痫中进一步加剧。
Protein oxidation has been demonstrated in preeclampsia, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). The present study comparatively evaluated ischemia modified albumin (IMA) and advanced oxidation protein products (AOPP) in different HDP and investigated their association with total antioxidant activity (AOA) and total thiols. There was a significant increase in AOPP and IMA, a significant decrease in AOA, total thiols and albumin in every HDP compared to controls. Among HDP groups, eclampsia patients showed more significant change in each of the parameter. IMA and AOPP were negatively associated with AOA in every HDP and with total thiols only in eclampsia. The present study supports the hypothesis of oxidative stress, as evidenced by increased protein oxidation, decreased antioxidant status and significant negative association between protein oxidation and AOA in every HDP. The imbalance of prooxidants and antioxidants was further augmented in eclampsia.