Possible steps involved in the transition to stationary adhesion of rolling neutrophils: A brief review
Possible steps involved in the transition to stationary adhesion of rolling neutrophils: A brief review
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DOI：
10.1038/sj.mn.7300122
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发表时间：
2000-12-01
期刊：
影响因子：
2.4
通讯作者：
Smith, CW
中科院分区：
文献类型：
--
作者：
Smith, CW
从滚动到牢固粘附的转变是当中性粒细胞在生理相关的剪切应力下与体外或体内活化的内皮相互作用时经常观察到的现象。导致这种激活的机制知之甚少，尽管已知涉及选择素依赖性束缚和CD 18-整合素依赖性粘附。这种转变可能涉及一系列的相互作用，触发足够的整合素激活，使细胞停滞在流动。最近的证据进行审查，在支持的概念，整合素（Mac-1和LFA-1）的激活信号，通过选择结合，趋化因子刺激，并可能发生的结果：LFA-1结合。
The transition from rolling to firm adhesion is a phenomenon frequently ob served when neutrophils are interacting with activated endothelium in vitro or in vivo under physiologically relevant shear stress. The mechanisms leading to this activation are poorly understood, though selectin-dependent tethering and CD18-integrin-dependent adhesion are known to be involved. This transition may involve a sequence of interactions that trigger sufficient integrin activation to allow cell arrest under flow. Recent evidence is reviewed in support of the concept that integrin (Mac-1 and LFA-1) activation results from signaling that occurs through select-in binding, chemotactic factor stimulation, and, possibly: LFA-1 binding.