Can food affect the bioavailability of chlorambucil in patients with haematological malignancies?
Can food affect the bioavailability of chlorambucil in patients with haematological malignancies?
复制标题
食物会影响血液恶性肿瘤患者中苯丁酸氮芥的生物利用度吗？
DOI：
--
复制
发表时间：
2004
影响因子：
3
通讯作者：
Z. Desai
中科院分区：
文献类型：
--
作者：
C. G. Adair;J. Bridges;Z. Desai
本文对10例血液病患者在化疗第一、二天进行了药代动力学研究。患者在空腹和非空腹条件下接受苯丁酸氮芥。通过反相高效液相色谱法测定苯丁酸氮芥的血浆浓度。通过Wilcoxon符号秩检验对非参数数据进行的统计学分析表明，食物导致血浆峰浓度（P <0.01）、消除速率常数（P <0.01）和血浆苯丁酸氮芥/时间曲线下面积（P = 0.01）显著降低。食物也能延长血药浓度达到峰值的时间（P <0.01）。肾功能与消除速率常数的回归分析显示，苯丁酸氮芥消除与肾功能无关（n = 8; r =-0.007; P = 0.72）。鉴于这些结果，我们建议，苯丁酸氮芥是空腹。
SummaryPharmacokinetic studies in ten patients with haematological disorders were undertaken on the first and second days of one course of chemotherapy. Patients received chlorambucil under fasting and non-fasting conditions. Plasma concentrations of chlorambucil were determined by a reversed-phase high-performance liquid chromatography assay. Statistical analysis by the Wilcoxon signed rank test for non-parametric data indicated that food caused a significant reduction in peak plasma levels (P<0.01), elimination rate constants (P<0.01) and area under the plasma chlorambucil/time curve (P=0.01). Food was also found to prolong the time taken to attain peak plasma levels (P<0.01). Regression analysis of renal function with elimination rate constants showed that chlorambucil elimination was independent of renal function (n=8; r=-0.007; P=0.72). In view of these results we suggest that chlorambucil is given on an empty stomach.
苯丁酸氮芥和美法仑在人体中的药代动力学比较。
DOI：
10.1007/978-3-642-81488-4_16
发表时间：
1980
期刊：
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
影响因子：
--
作者：
Alberts,DS;Chang,SY;Chen,HS;Larcom,BJ;Evans,TL
通讯作者：
Evans,TL