Estimation of kinetic model parameters in fluorescence optical diffusion tomography
Estimation of kinetic model parameters in fluorescence optical diffusion tomography
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DOI：
10.1364/josaa.22.001357
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发表时间：
2005-07-01
影响因子：
1.9
通讯作者：
Bouman, CA
中科院分区：
文献类型：
--
作者：
Milstein, AB;Webb, KJ;Bouman, CA
我们提出了一种在浑浊介质中重建荧光造影剂的空间依赖动力学的技术。动力行为是由室室模型的线性和非线性参数或具有确定性函数形式的其他模型来描述的。该方法通过参数化重建随时间变化的荧光产率，扩展了我们以前在荧光光学扩散层析成像中的工作。重构采用贝叶斯框架和参数迭代坐标下降优化，与高斯-塞德尔方法密切相关。通过仿真研究验证了该方法的有效性。(C) 2005年美国光学学会。
We present a technique for reconstructing the spatially dependent dynamics of a fluorescent contrast agent in turbid media. The dynamic behavior is described by linear and nonlinear parameters of a compartmental model or some other model with a deterministic functional form. The method extends our previous work in fluorescence optical diffusion tomography by parametrically reconstructing the time-dependent fluorescent yield. The reconstruction uses a Bayesian framework and parametric iterative coordinate descent optimization, which is closely related to Gauss-Seidel methods. We demonstrate the method with a simulation study. (C) 2005 Optical Society of America.