Chemical structure of posttranslational modification with a Farnesyl group on tryptophan
Chemical structure of posttranslational modification with a Farnesyl group on tryptophan
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DOI：
10.1271/bbb.80006
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发表时间：
2008-03-01
影响因子：
1.6
通讯作者：
Sakagami, Youji
中科院分区：
文献类型：
--
作者：
Okada, Masahiro;Yamaguchi, Hisao;Sakagami, Youji
枯草芽孢杆菌和相关的芽孢杆菌产生一种后修饰的寡肽，ComX信息素，刺激由群体感应控制的天然遗传能力。来自菌株RO-C-2的ComXRO-C-2信息素必须在Trp残基上用法尼基基团修饰，但精确结构尚不清楚。在这里，我们报告的精确性质的翻译后法尼基化的ComXRO-C-2信息素的色氨酸残基，导致形成的三环结构。由研究B的标准实验室菌株产生的ComX（168）信息素。枯草群岛也根据系统发育相似性后法尼基化。
Bacillus subtilis and related bacilli produce a posttranslationally modified oligopeptide, the ComX pheromone, that stimulates natural genetic competence controlled by quorum sensing. The ComXRO-C-2 pheromone from strain RO-C-2 must be modified with a farnesyl group on the Trp residue, but the precise structure is not known. Here we report the precise nature of posttranslational farnesylation of ComXRO-C-2 pheromone on the Trp residue, resulting in the formation of a tricyclic structure. The ComX(168) pheromone, produced by the, standard laboratory strain used in the study of B. subtilis, is. also posttranslationally farnesylated according to phylogenetic resemblance.