Curcumin attenuates surgery-induced cognitive dysfunction in aged mice
Curcumin attenuates surgery-induced cognitive dysfunction in aged mice
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姜黄素减轻手术引起的老年小鼠认知功能障碍
DOI：
10.1007/s11011-017-9970-y
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发表时间：
2017-06-01
影响因子：
3.6
通讯作者：
Cui, Wei
中科院分区：
文献类型：
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作者：
Wu, Xiang;Chen, Huixin;Cui, Wei
术后认知功能障碍（POCD）与接受手术的老年患者有关。然而，POCD的药物治疗是有限的。在这项研究中，我们发现姜黄素，一种来自姜黄的活性化合物，改善老年小鼠腹部手术后的认知功能障碍。此外，姜黄素阻止手术诱导的抗氧化酶活性。姜黄素还增加了脑源性神经营养因子（BDNF）阳性面积和pAkt在脑中的表达，表明姜黄素激活了老年小鼠的BDNF信号转导。此外，姜黄素中和胆碱能功能障碍，涉及胆碱乙酰转移酶的表达诱导手术。这些结果强烈表明，姜黄素通过多个靶点预防认知障碍，可能是通过同时增加抗氧化酶的活性、激活BDNF信号传导和中和胆碱能功能障碍。基于这些新的发现，姜黄素可能是POCD预防和治疗的潜在药物。
Post-operative cognitive dysfunction (POCD) is associated with elderly patients undergoing surgery. However, pharmacological treatments for POCD are limited. In this study, we found that curcumin, an active compound derived fromCurcuma longa, ameliorated the cognitive dysfunction following abdominal surgery in aged mice. Further, curcumin prevented surgery-induced anti-oxidant enzyme activity. Curcumin also increased brain-derived neurotrophic factor (BDNF)-positive area and expression of pAkt in the brain, suggesting that curcumin activated BDNF signaling in aged mice. Furthermore, curcumin neutralized cholinergic dysfunction involving choline acetyltransferase expression induced by surgery. These results strongly suggested that curcumin prevented cognitive impairments via multiple targets, possibly by increasing the activity of anti-oxidant enzymes, activation of BDNF signaling, and neutralization of cholinergic dysfunction, concurrently. Based on these novel findings, curcumin might be a potential agent in POCD prophylaxis and treatment.