Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain.
Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain.
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DOI：
10.3389/fphys.2017.00895
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发表时间：
2017
影响因子：
4
通讯作者：
Rodrigues-Mascarenhas S
中科院分区：
文献类型：
--
作者：
Cavalcante-Silva LHA;Lima ÉA;Carvalho DCM;de Sales-Neto JM;Alves AKA;Galvão JGFM;da Silva JSF;Rodrigues-Mascarenhas S
自从发现哇巴因作为高等哺乳动物中存在的强心类固醇激素以来，对其的研究进展迅速，并且已经描述了其一些生理和药理作用。哇巴因可以作为一种应激激素，肾上腺皮质是其主要来源。哇巴因的直接作用源于其受体 Na+/K+-ATP 酶与靶细胞的结合。这种相互作用可以促进 Na+ 转运阻断甚至信号转导途径的激活（例如 EGFR/Src-Ras-ERK 途径激活），与离子转运无关。除了众所周知的哇巴因对心血管系统和血压控制的作用外，令人信服的证据表明哇巴因还可以调节许多免疫功能。炎症是一种紧密协调的免疫功能，也受到哇巴因的影响。事实上，这种激素可以调节许多炎症事件，例如细胞迁移、血管通透性和细胞因子的产生。此外，哇巴因还干扰神经炎症。然而，尚不清楚哇巴因如何控制这些事件。在这篇简短的综述中，我们总结了哇巴因在外周和中枢炎症的几个方面的作用的最新进展，为哇巴因对免疫系统的功能带来了新的见解。
Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described. Ouabain can behave as a stress hormone and adrenal cortex is its main source. Direct effects of ouabain are originated due to the binding to its receptor, the Na+/K+-ATPase, on target cells. This interaction can promote Na+ transport blockade or even activation of signaling transduction pathways (e.g., EGFR/Src-Ras-ERK pathway activation), independent of ion transport. Besides the well-known effect of ouabain on the cardiovascular system and blood pressure control, compelling evidence indicates that ouabain regulates a number of immune functions. Inflammation is a tightly coordinated immunological function that is also affected by ouabain. Indeed, this hormone can modulate many inflammatory events such as cell migration, vascular permeability, and cytokine production. Moreover, ouabain also interferes on neuroinflammation. However, it is not clear how ouabain controls these events. In this brief review, we summarize the updates of ouabain effect on several aspects of peripheral and central inflammation, bringing new insights into ouabain functions on the immune system.
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影响因子：
21.1
作者：
Bagrov AY;Shapiro JI;Fedorova OV
通讯作者：
Fedorova OV
影响因子：
11.1
作者：
Dan C;Jinjun B;Zi-Chun H;Lin M;Wei C;Xu Z;Ri Z;Shun C;Wen-Zhu S;Qing-Cai J;Wu Y
通讯作者：
Wu Y
影响因子：
13.6
作者：
Dvela-Levitt, Moran;Cohen-Ben Ami, Hagit;Lichtstein, David
通讯作者：
Lichtstein, David
影响因子：
8.8
作者：
Berendes, E;Cullen, P;Walter, M
通讯作者：
Walter, M
DOI：
10.1016/s0167-4889(96)00116-4
发表时间：
1997-01-10
影响因子：
5.1
作者：
Foey, AD;Crawford, A;Hall, ND
通讯作者：
Hall, ND