Monitoring both serum amyloid protein A and C-reactive protein as inflammatory markers in infectious diseases.
Monitoring both serum amyloid protein A and C-reactive protein as inflammatory markers in infectious diseases.
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监测血清淀粉样蛋白 A 和 C 反应蛋白作为传染病炎症标志物。
作者：
Tetsuo Nakayama;S. Sonoda;Takashi Urano;T. Yamada;M. Okada
我们检测了血清淀粉样蛋白A（SAA）和C反应蛋白（CRP）作为病毒和细菌感染的炎症标志物。两种急性期反应物在急性期增加，此后在恢复期减少。在病毒感染中，急性期SAA的平均血清浓度为腺病毒感染141 mg/L，麻疹病毒77 mg/L，流感病毒63 mg/L，副流感病毒55 mg/L，呼吸道合胞病毒31 mg/L，无菌性脑膜炎31 mg/L。腺病毒感染的CRP平均血清浓度为19 mg/L，所有其他病毒感染的CRP平均血清浓度< 7 mg/L。SAA浓度是CRP浓度的5- 11倍。SAA和CRP浓度在细菌感染中均高于病毒感染。细菌感染时血清SAA浓度的变化与血清CRP的变化平行;然而，在病毒感染过程中，血清SAA往往比CRP消失得更快。SAA似乎是急性病毒感染中临床上有用的炎症标志物，有或没有CRP浓度的显著变化。
We examined serum amyloid protein A (SAA) and C-reactive protein (CRP) as inflammatory markers of viral and bacterial infections. Both acute-phase reactants increased in the acute stage and thereafter decreased in the convalescent stage. In viral infections, the mean serum concentrations of SAA during the acute stage were 141 mg/L in infections with adenovirus, 77 mg/L with measles virus, 63 mg/L with influenza virus, 55 mg/L with parainfluenza virus, 31 mg/L with respiratory syncytial virus, and 31 mg/L in aseptic meningitis. The mean serum concentration of CRP was 19 mg/L for adenovirus infection and < 7 mg/L in all other viral infections. The SAA concentrations were 5- to 11-fold greater than the CRP concentrations. Both the SAA and the CRP concentrations were higher in bacterial infections than in viral infections. Changes in the concentrations of serum SAA paralleled those in serum CRP in bacterial infection; during the course of viral infection, however, serum SAA tended to disappear more quickly than CRP did. SAA appears to be a clinically useful marker of inflammation in acute viral infections, with or without significant changes in the CRP concentration.