Dietary factors and breast cancer.
Dietary factors and breast cancer.
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饮食因素与乳腺癌。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
D. Rose
中科院分区：
文献类型：
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作者：
D. Rose
人群和病例对照研究表明，饮食参与乳腺癌的病因。肥胖似乎是绝经后疾病的一个危险因素，并且最有可能通过雌激素合成和代谢的改变而起作用。膳食脂肪虽然是热量的主要来源，因此也是导致肥胖症的一个因素，但可能具有更具体的作用，涉及雌激素、蛋白质激素和生长因子，或其他非内分泌机制。肥胖对乳腺癌术后预后也有不利影响。同样，这可能，至少部分地，涉及绝经后患者残留肿瘤的增强雌激素刺激。虽然这些关系的知识可以通过应用适当的动物模型来扩展，但最终的测试必须是在乳腺癌高危妇女群体中实施精心设计的干预试验，并作为乳腺癌患者手术的辅助手段。
Population and case-control studies indicate the involvement of diet in breast cancer aetiology. Obesity appears to be a risk factor for postmenopausal disease, and most likely operates through the modification of oestrogen synthesis and metabolism. Dietary fat, though a major source of calories and, therefore, a contributor to the development of obesity, may have a more specific role, involving oestrogens, protein hormones and growth factors, or other, non-endocrine, mechanisms. Obesity also has an adverse effect on breast cancer prognosis after surgery. Again, this may, at least partially, involve enhanced oestrogenic stimulation of residual tumours in postmenopausal patients. Though knowledge of these relationships can be expanded by the application of appropriate animal models, the final test has to be the implementation of carefully designed intervention trials in groups of women at high risk of breast cancer, and as an adjunct to surgery in breast cancer patients.