Update in occupational and environmental respiratory disease 2007
Update in occupational and environmental respiratory disease 2007
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DOI：
10.1164/rccm.200801-116up
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发表时间：
2008-04-01
影响因子：
24.7
通讯作者：
Nemery, Benoit
中科院分区：
文献类型：
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作者：
Nawrot, Tim S.;Alfaro-Moreno, Ernesto;Nemery, Benoit
2007年发表了几项原创性流行病学研究，表明特定环境或职业暴露与不良呼吸道影响之间存在关联。在大量人群中进行的这类研究，不可避免地依赖于粗略的终点，如死亡率、通过问卷获得的呼吸道症状或简单的肺功能测量。尽管这种观察性研究可能指出(假定的)暴露与疾病之间的因果联系，但它们必须通过使用更精细的终点和/或更复杂的设计的进一步流行病学研究，以及为观察到的发现提供似是而非和机械解释所需的实验研究来完成。因此，考夫曼(1)在一篇社论中指出了整合流行病学和毒理学方法以阐明空气污染对健康影响的机制的重要性。
Several original epidemiologic studies showing associations between specific environmental or occupational exposures and adverse respiratory effects were published in 2007. Such studies in large populations often rely, by necessity, on crude endpoints, such as mortality, respiratory symptoms obtained by questionnaires, or simple pulmonary function measurements. Although such observational studies may point to causal links between (presumed) exposure and disease, they must be completed by further epidemiologic studies that use more refined endpoints and/or more sophisticated designs, and by experimental studies that are needed to provide plausibility as well as mechanistic explanations for the observed findings. Thus, in an editorial, Kaufman (1) pointed to the importance to integrate epidemiologic and toxicology approaches to elucidate the mechanism of the effects of air pollution on health.