ACTIVATION OF A CELLULAR ONC GENE BY PROMOTER INSERTION IN ALV-INDUCED LYMPHOID LEUKOSIS
ACTIVATION OF A CELLULAR ONC GENE BY PROMOTER INSERTION IN ALV-INDUCED LYMPHOID LEUKOSIS
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DOI：
10.1038/290475a0
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发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
ASTRIN, SM
中科院分区：
文献类型：
--
作者：
HAYWARD, WS;NEEL, BG;ASTRIN, SM
对禽白血病病毒（ALV）诱导的淋巴瘤的DNA和RNA的分析提供了强有力的证据，即在大多数肿瘤中，ALV通过激活MC 29病毒转化基因的细胞对应物c-myc基因诱导肿瘤性疾病。作为一种罕见的事件，ALV前病毒整合到c-myc基因附近，并且从病毒启动子开始的转录导致c-myc表达增强，导致肿瘤转化。
Analyses of DNA and RNA from avian leukosis virus (ALV)-induced lymphomas [in birds] have provided strong evidence that, in most tumors, ALV induces neoplastic disease by activating the c-myc gene, the cellular counterpart of the transforming gene of MC29 virus. As a rare event, the ALV provirus integrates adjacent to the c-myc gene and that transcription, initiating from a viral promoter, causes enhanced expression of c-myc, leading to neoplastic transformation.