Structural and functional characterization of the promoter region of the mouse c-Ki-ras gene.
Structural and functional characterization of the promoter region of the mouse c-Ki-ras gene.
复制标题
小鼠 c-Ki-ras 基因启动子区域的结构和功能表征。
DOI：
10.1128/mcb.7.7.2592-2596.1987
复制
发表时间：
1987
影响因子：
5.3
通讯作者：
George,DL
中科院分区：
文献类型：
--
作者：
Hoffman,EK;Trusko,SP;Freeman,N;George,DL
We isolated and characterized the 5′ region of the mouse c-Ki-rasgene, including a 5′ untranslated exon (exon 0). These studies used genetic material from Y1 mouse adrenocortical tumor cells in which the c-Ki-rasgene is amplified and overexpressed. Our data demonstrate that transcription initiates at multiple sites, predicting size heterogeneity at the 5′ ends of the c-Ki-rasmRNAs. Using transient expression assays, we identified a genomic fragment within the 5′ region which exhibits bidirectional promoter activity.
