CALCIUM-DEPENDENT SPIKE AFTER-CURRENT INDUCES BURST FIRING IN MAGNOCELLULAR NEUROSECRETORY-CELLS
CALCIUM-DEPENDENT SPIKE AFTER-CURRENT INDUCES BURST FIRING IN MAGNOCELLULAR NEUROSECRETORY-CELLS
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DOI：
10.1016/0304-3940(86)90464-7
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发表时间：
1986-10-08
影响因子：
2.5
通讯作者：
BOURQUE, CW
中科院分区：
文献类型：
--
作者：
BOURQUE, CW
将大细胞神经分泌细胞（MNC）刺入大鼠下丘脑的灌注外植体中。在 1-5 个电流诱发尖峰后应用电压钳显示出抗河豚毒素但对 Cd2+ 敏感的内向电流。从接近 -85 mV 的阈值开始，该电流的幅度随着后尖峰命令变得更正电位而增加。激活后，电池的电流电压关系显示出一个超过尖峰阈值的负电阻区域。因此，这种依赖于 Ca2+ 的尖峰后电流可以诱导并维持跨国公司的爆发放电。
Magnocellular neurosecretory cells (MNCs) were impaled in perfused explants of rat hypothalamus. Application of a voltage clamp after 1-5 current-evoked spikes revealed a tetrodotoxin-resistant, but Cd2+-sensitive inward current. From a threshold near -85 mV, the amplitude of this current increased as postspike commands were made to more positive potentials. Following its activation, the current voltage relation of the cell displayed a region of negative resistance which crossed the spike threshold. This Ca2+-dependent spike after-current can therefore induce and sustain burst firing in MNCs.