The role of microRNAs in skeletal muscle health and disease.
The role of microRNAs in skeletal muscle health and disease.
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DOI：
10.2741/4298
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
McCarthy JJ
中科院分区：
文献类型：
--
作者：
Kirby TJ;Chaillou T;McCarthy JJ
在过去的十年里，非编码RNA已经成为基因表达的重要调节者。特别是，microRNAs是一类约22个核苷酸的小RNA，通过转录后机制抑制基因表达。MicroRNAs已被证明参与了更广泛的生物过程，包括生理和病理过程，包括肌肉发生、运动适应和各种肌病。这篇综述的目的是对目前已知的microRNAs在骨骼肌健康和疾病中的作用进行全面的总结。
Over the last decade non-coding RNAs have emerged as importance regulators of gene expression. In particular, microRNAs are a class of small RNAs of ~ 22 nucleotides that repress gene expression through a post-transcriptional mechanism. MicroRNAs have been shown to be involved in a broader range of biological processes, both physiological and pathological, including myogenesis, adaptation to exercise and various myopathies. The purpose of this review is to provide a comprehensive summary of what is currently known about the role of microRNAs in skeletal muscle health and disease.