Antinociceptive and cardiovascular properties of esmolol following formalin injection in rats
Antinociceptive and cardiovascular properties of esmolol following formalin injection in rats
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DOI：
10.1007/bf03019816
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发表时间：
2001-01-01
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影响因子：
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通讯作者：
Chelly, JE
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文献类型：
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作者：
Davidson, EM;Doursout, MF;Chelly, JE
目的：探讨β(1)受体阻滞剂艾司洛尔在无麻醉状态下对疼痛的调节作用。方法：慢性记录平均动脉压(MAP)和心率(HR)。动物被分成三组。I组[艾司洛尔高(EH)150 mg·kg(-1)·hr(-1)；n=9]，2组[艾司洛尔低(EL)40 mg·kg(-1)hr(-1)；n=7]，3组生理盐水(n=9)。大鼠后爪注射5%福尔马林。结果：福尔马林组大鼠伤害性反应早期(1期，0~5min)，晚期(2期，10~35min)。小剂量艾司洛尔对伤害性第二时相的影响最小，但大剂量艾司洛尔对伤害性第二时相的影响较小。福尔马林诱导的MAP和HR呈双相升高。虽然艾司洛尔不影响MAP的初始升高，但大剂量的艾司洛尔可减弱MAP的继发性升高。低剂量和高剂量的艾司洛尔均可抑制福尔马林诱发的前30分钟内的心动过速。结论：艾司洛尔具有镇痛作用，可降低心血管对疼痛的反应。
Purpose: To assess the role of esmolol, a beta (1) receptor blocker, in the modulation of pain in the absence of anesthesia.Methods: Rats were chronically instrumented to record mean arterial blood pressure (MAP) and heart rate (HR). Animals were divided into three groups. Group I [esmolol high(EH) 150 mg.kg(-1).hr(-1); n=9], Group 2 [esmolol low (EL) 40 mg.kg(-1)hr(-1); n=7] and Group 3 saline (n = 9). Formalin 5% was injected in the rat hind paw. Formalin-induced lifting, MAP and HR were recorded at five minute intervals for 35 min after formalin injection.Results: Formalin was associated with an early(Phase 1; 0-5 min) and late nociceptive response (Phase 2; 10-35 min). Esmolol did not affect Phase 1. Although low dose esmolol had minimum effects on nociceptive Phase 2, it was diminished with high dose esmolol. Formalin induced biphasic increases in MAP and HR. Although esmolol did not affect the initial increase in MAP, high dose esmolol blunted the secondary increase in MAP Both low and high doses of esmolol inhibited formalin-induced tachycardia during the first 30 min.Conclusion: Our data suggest that esmolol leads to analgesia and reduction of cardiovascular responses to pain.