Omeprazole 10 milligrams once daily, omeprazole 20 milligrams once daily, or ranitidine 150 milligrams twice daily, evaluated as initial therapy for the relief of symptoms of gastro-oesophageal reflux disease in general practice.
Omeprazole 10 milligrams once daily, omeprazole 20 milligrams once daily, or ranitidine 150 milligrams twice daily, evaluated as initial therapy for the relief of symptoms of gastro-oesophageal reflux disease in general practice.
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奥美拉唑 10 毫克，每日一次，奥美拉唑 20 毫克，每日一次，或雷尼替丁 150 毫克，每日两次，在一般实践中作为缓解胃食管反流病症状的初始治疗进行评估。
DOI：
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发表时间：
1997
影响因子：
1.9
通讯作者：
M. Turbitt
中科院分区：
文献类型：
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作者：
T. L. Venables;R. Newland;A. C. Patel;J. Hole;C. Wilcock;M. Turbitt
背景
奥美拉唑（20 mg，每日一次）治疗反流性食管炎的疗效以及相对于组胺H2受体拮抗剂的治疗优势已得到充分证明。本研究评估了20 mg奥美拉唑每日一次（OM 20）、10 mg奥美拉唑每日一次（OM 10）和150 mg雷尼替丁（RAN）每日两次对胃食管反流病（GORD）症状缓解的影响。
方法
向全科医生就诊的胃灼热患者（n = 994）接受内镜检查以排除消化性溃疡疾病，并随机分配至英国多中心、平行组、双盲比较三种治疗4周。在2周和4周后的临床访视时评估症状。
结果
4周后症状缓解率分别为61%（OM 20）、49%（OM 10）和40%（RAN）（OM 20 vs OM 10，P < 0.0167; OM 20 vs RAN，P < 0.0001; OM 10 vs RAN，P < 0.01）。在糜烂性反流性食管炎患者（32%）中，79%（OM 20）、48%（OM 10）和33%（RAN）的症状缓解（OM 20 vs OM 10，P < 0.0001; OM 20 vs RAN，P < 0.0001; OM 10 vs RAN，NS）。
结论
奥美拉唑，20毫克，是最有效的初始治疗缓解GORD症状。
BACKGROUND
The efficacy of omeprazole, 20 mg once daily, in the treatment of reflux oesophagitis and the therapeutic advantages over the histamine H2 receptor antagonists are well documented. This study assessed 20 mg omeprazole daily (OM20), 10 mg omeprazole daily (OM10), and 150 mg ranitidine (RAN) twice daily for symptom relief in gastro-oesophageal reflux disease (GORD).
METHODS
Patients (n = 994) presenting with heartburn to their general practitioner underwent endoscopy to exclude peptic ulcer disease and were randomized into a UK, multicentre, parallel-group, double-blind comparison of the three treatments for 4 weeks. Symptoms were assessed at clinic visits after 2 and 4 weeks.
RESULTS
Symptom relief after 4 weeks was achieved by 61% (OM20), 49% (OM10), and 40% (RAN) patients (OM20 versus OM10, P < 0.0167; OM20 versus RAN, P < 0.0001; OM10 versus RAN, P < 0.01). Among the patients (32%) with erosive reflux oesophagitis, symptom relief was achieved in 79% (OM20), 48% (OM10), and 33% (RAN) (OM20 versus OM10, P < 0.0001; OM20 versus RAN, P < 0.0001; OM1O versus RAN, NS).
CONCLUSION
Omeprazole, 20 mg, is the most effective initial therapy for relief of GORD symptoms.