BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients
BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients
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DOI：
10.1016/j.canlet.2008.08.001
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发表时间：
2009-01-18
期刊：
影响因子：
9.7
通讯作者：
Iacopetta, Barry
中科院分区：
文献类型：
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作者：
Ang, Pei Woon;Li, Wei Qi;Iacopetta, Barry
本研究旨在探讨年轻结直肠癌（CRC）患者BPAF突变、CpG岛甲基化表型（CIMP+）和APC甲基化之间的关系。V600 E BRAF突变在7%的病例中发现，与近端部位、晚期和组织学分级差的肿瘤特征密切相关。超过一半（53%）具有BRAF突变的肿瘤也是CIMP+，如通过一组标准标记物评估的，而具有野生型BRAF的肿瘤仅为4%（P < 0.0001）。与CIMP+相比，APC甲基化与BRAF突变呈负相关（P = 0.02）。因此，BRAF突变和CIMP+可能参与年轻患者CRC发展过程中APC失活的替代（尽管罕见）途径。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
This study investigated the relationship between BPAF mutation, the CpG island methylator phenotype (CIMP+) and APC methylation in colorectal cancer (CRC) from young patients. The V600E BRAF mutation was found in 7% of cases and was strongly associated with the tumour features of proximal site, advanced stage and poor histological grade. More than half (53%) the tumours with BRAF mutation were also CIMP+ as evaluated by a standard panel of markers, compared to only 4% of tumours with wildtype BRAF (P < 0.0001). In contrast to CIMP+, APC methylation was inversely correlated with BRAF mutation (P = 0.02). BRAF mutation and CIMP+ are therefore likely to be involved in an alternate, albeit rare, pathway to APC inactivation during the development of CRC in younger patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved.