Gargantulide A, a Complex 52-Membered Macrolactone Showing Antibacterial Activity from Streptomyces sp.
Gargantulide A, a Complex 52-Membered Macrolactone Showing Antibacterial Activity from Streptomyces sp.
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DOI：
10.1021/acs.orglett.5b00068
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发表时间：
2015-03-20
期刊：
影响因子：
5.2
通讯作者：
Gerwick, William H.
中科院分区：
文献类型：
--
作者：
Rho, Jung-Rae;Subramaniam, Gurusamy;Gerwick, William H.
Gargantulide A（1）是一种极其复杂的52元大环内酯，从链霉菌A42983中分离得到，对MRSA具有中等活性。利用2D NMR确定了化合物1的平面结构，并基于NOESY关联、J-构型分析和Kishis通用NMR数据库部分建立了化合物1的立体化学。
Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishis universal NMR database.