NOS Expression and NO Function in Glioma and Implications for Patient Therapies.
NOS Expression and NO Function in Glioma and Implications for Patient Therapies.
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DOI：
10.1089/ars.2016.6820
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发表时间：
2017-06
影响因子：
6.6
通讯作者：
A. Tran;Nathaniel H. Boyd;Kiera Walker;A. Hjelmeland
中科院分区：
文献类型：
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作者：
A. Tran;Nathaniel H. Boyd;Kiera Walker;A. Hjelmeland
意义胶质瘤是一种中枢神经系统肿瘤，主要发生在大脑，起源于神经胶质细胞。胶质瘤包括成人最常见的恶性脑瘤，称为IV级星形细胞瘤，或胶质母细胞瘤(GBM)。基底膜是一种致命的疾病，治疗上最显著的进步仅能提高∼2个月的存活率。为了开发新的治疗方法和改善患者预后，我们和其他人试图确定分子信号在胶质瘤中的作用。最新进展：在胶质瘤中介导重要生物学行为的一个信号分子是自由基一氧化氮(NO)。在胶质瘤细胞和肿瘤微环境中，NO由一氧化氮合酶(NOS)的三种亚型NOS1、NOS2和NOS3产生。NO和NOS影响胶质瘤的生长、侵袭、血管生成、免疫抑制、分化状态和治疗耐药。在体外和体内，NO和NOS对胶质瘤的这些多方面的作用表明，未来有可能调节抗胶质瘤患者的治疗途径。抗氧化剂。氧化还原信号。26,986-999。
SIGNIFICANCE Gliomas are central nervous system tumors that primarily occur in the brain and arise from glial cells. Gliomas include the most common malignant brain tumor in adults known as grade IV astrocytoma, or glioblastoma (GBM). GBM is a deadly disease for which the most significant advances in treatment offer an improvement in survival of only ∼2 months. CRITICAL ISSUES To develop novel treatments and improve patient outcomes, we and others have sought to determine the role of molecular signals in gliomas. Recent Advances: One signaling molecule that mediates important biologies in glioma is the free radical nitric oxide (NO). In glioma cells and the tumor microenvironment, NO is produced by three isoforms of nitric oxide synthase (NOS), NOS1, NOS2, and NOS3. NO and NOS affect glioma growth, invasion, angiogenesis, immunosuppression, differentiation state, and therapeutic resistance. FUTURE DIRECTIONS These multifaceted effects of NO and NOS on gliomas both in vitro and in vivo suggest the potential of modulating the pathway for antiglioma patient therapies. Antioxid. Redox Signal. 26, 986-999.