CGMP ACTS WITHIN CEREBELLAR PURKINJE-CELLS TO PRODUCE LONG-TERM DEPRESSION VIA MECHANISMS INVOLVING PKC AND PKG
CGMP ACTS WITHIN CEREBELLAR PURKINJE-CELLS TO PRODUCE LONG-TERM DEPRESSION VIA MECHANISMS INVOLVING PKC AND PKG
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DOI：
10.1097/00001756-199403000-00024
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发表时间：
1994-03-21
期刊：
影响因子：
1.7
通讯作者：
HARTELL, NA
中科院分区：
文献类型：
--
作者：
HARTELL, NA
LONG term depression (LTD) of parallel fibre-Purkinje cell responses may result from desensitization of AMFA (alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid) type glutamate receptors, for which a cascade of reactions involving calcium, inositol-1,4,5-trisphosphate, nitric oxide (NO), guanosine-3'5'-monophosphate (cGMP) and protein kinases C and G has been previously proposed. The involvement of cGMP in synaptic LTD was confirmed by direct injection of cGMP and 8-bromo-cGMP (8-Br-cGMF) into the dendrites of Purkinje cells. Fairing injections with parallel fibre stimulation led to a LTD of synaptic transmission which both occluded and was occluded by heterosynaptically induced LTD. Inhibition of either protein kinases C or G prevented induction of both forms of LTD.
