Characterization of the LPS-induced inflammation of the adrenal gland in mice
Characterization of the LPS-induced inflammation of the adrenal gland in mice
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DOI：
10.1016/j.mce.2012.12.020
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发表时间：
2013-05-22
影响因子：
4.1
通讯作者：
Bornstein, Stefan R.
中科院分区：
文献类型：
--
作者：
Kanczkowski, Waldemar;Chatzigeorgiou, Antonios;Bornstein, Stefan R.
内毒素与细菌诱导的全身性炎症反应综合征（SIRS）非常相似，全身给药可最终导致器官衰竭。肾上腺功能不全常被诊断为危重患者；然而，其潜在机制尚不清楚。在本研究中，我们全面研究了lps诱导的小鼠全身性炎症过程中肾上腺功能失调的特点，包括炎症、白细胞浸润和细胞死亡。LPS增强了许多促炎细胞因子、趋化因子和粘附分子的表达，导致白细胞快速募集到肾上腺。此外，脂多糖介导的炎症与肾上腺皮质细胞和染色质细胞凋亡增加有关。我们在小鼠中进行的研究结果表明，lps诱导的肾上腺炎症和细胞死亡可能是脓毒症患者肾上腺功能障碍的潜在机制。2012爱思唯尔爱尔兰有限公司版权所有。
Systemic administration of endotoxin, which closely mimics the bacteria-induced systemic inflammatory response syndrome (SIRS) can ultimately lead to organ failure. Adrenal gland insufficiency is frequently diagnosed in critically ill patients; however, the underlying mechanisms are still unclear. In the present study, we studied comprehensively the characteristics of adrenal gland dysregulation, including inflammation, leukocyte infiltration and cell death in the adrenal glands in the course of LPS-induced systemic inflammation in mice. LPS enhanced expression of many proinflammatory cytokines, chemokines and adhesion molecules, which resulted in rapid recruitment of leukocytes into the adrenal gland. Furthermore, LPS-mediated inflammation was associated with increased apoptosis of adrenocortical and chromaffin cells. Our results performed in mice, suggest that LPS-induced adrenal gland inflammation and cell death might be mechanisms potentially involved in the adrenal gland dysfunction in patients with sepsis. (c) 2012 Elsevier Ireland Ltd. All rights reserved.