Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes
Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes
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DOI：
10.1016/j.immuni.2006.10.011
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发表时间：
2006-12-01
期刊：
影响因子：
32.4
通讯作者：
Germain, Ronald N.
中科院分区：
文献类型：
--
作者：
Bajenoff, Marc;Egen, Jackson G.;Germain, Ronald N.
在进入淋巴结（LN）后，B细胞迁移到滤泡，而T细胞保留在副皮质中，每种淋巴细胞类型在这些不同的区域内表现出明显的随机迁移。除趋化因子外，导致这种空间分离和观察到的淋巴细胞运动模式的因素的特征很差。通过结合共聚焦，电子和活体显微镜，我们表明，成纤维细胞网状细胞网络调节幼稚T细胞进入副皮质，也支持和定义的限制T细胞运动在这个领域，而一个独特的滤泡树突状细胞网络同样作为基层的滤泡B细胞的运动。这些结果强调了基质显微解剖在协调LN内细胞迁移中的核心作用。
After entry into lymph nodes (LNs), B cells migrate to follicles, whereas T cells remain in the paracortex, with each lymphocyte type showing apparently random migration within these distinct areas. Other than chemokines, the factors contributing to this spatial segregation and to the observed patterns of lymphocyte movement are poorly characterized. By combining confocal, electron, and intravital microscopy, we showed that the fibroblastic reticular cell network regulated naive T cell access to the paracortex and also supported and defined the limits of T cell movement within this domain, whereas a distinct follicular dendritic cell network similarly served as the substratum for movement of follicular B cells. These results highlight the central role of stromal microanatomy in orchestrating cell migration within the LN.