Thyroid hormone regulation of rat pituitary tumor cell growth: a new role for apotransferrin as an autocrine thyromedin.
Thyroid hormone regulation of rat pituitary tumor cell growth: a new role for apotransferrin as an autocrine thyromedin.
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甲状腺激素对大鼠垂体肿瘤细胞生长的调节：脱铁转铁蛋白作为自分泌甲状腺调节素的新作用。
DOI：
10.1016/0303-7207(91)90053-u
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发表时间：
1991
影响因子：
4.1
通讯作者：
Eby,JE
中科院分区：
文献类型：
--
作者：
Sirbasku,DA;Pakala,R;Sato,H;Eby,JE
在40年的转铁蛋白研究中，载转铁蛋白除了作为膳食铁和储存铁的血浆载体外，没有其他作用被认识到。我们的研究揭示了该分子的一种新的“自分泌”生长作用，以及一种可能的新的细胞-细胞桥/CAM功能。当然，这些观察结果为甲状腺激素的作用和转铁蛋白的功能开辟了许多新的研究领域。此外，现在有一个更广泛的问题，即垂体以外的组织可能利用转铁蛋白来调节对甲状腺激素的反应。
In the 40 years of transferrin research, no previous role for apotransferrin has been recognized other than to serve as a plasma carrier for dietary and storage iron. Our studies have revealed a new'autocrine'growth role for this molecule as well as a possible new cell-cell bridge/CAM function. Certainly, these observations have opened many new areas of investigation both with regard to thyroid hormone action and the function of apotransferrin. In addition, there is now accessible the broader question of tissues other than pituitary which might utilize apotransferrin to regulate responsiveness to thyroid hormones.