Readily releasable pool size changes associated with long term depression
Readily releasable pool size changes associated with long term depression
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DOI：
10.1073/pnas.95.3.1283
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发表时间：
1998-02-03
影响因子：
11.1
通讯作者：
Stevens, CF
中科院分区：
文献类型：
--
作者：
Goda, Y;Stevens, CF
对于培养物中的海马神经元，我们估计了在产生培养物长期抑郁（LTD）的刺激之前和之后自动释放的易于释放池的大小。这种刺激方案会导致池大小的减小，其大小与突触电流的抑制成正比。为了确定该系统中的抑郁是否是突触特异性的而不是普遍的，我们还监测了自动且相互互连的培养的海马神经元对之间的突触传递。我们发现突触强度的变化仅限于在 LTD 诱导期间活跃的目标神经元上的突触。然而，从突触前神经元的角度来看，突触特异性是部分的而不是完整的：诱导期间不在目标神经元上的活跃突触被部分抑制。
We have estimated, for hippocampal neurons in culture, the size of the autaptic readily releasable pool before and after stimulation of the sort that produces culture Long term depression (LTD). This stimulation protocol causes a decrease in the pool size that is proportional to the depression of synaptic currents. To determine if depression in this system is synapse specific rather than general, we have also monitored synaptic transmission between pairs of cultured hippocampal neurons that are autaptically and reciprocally interconnected. We find that the change in synaptic strength is restricted to the synapses on the target neuron that were active during LTD induction. When viewed from the perspective of the presynaptic neuron, however, synapse specificity is partial rather than complete: synapses active during induction that were not on the target neuron were partially depressed.