THE CHOICE OF CELL FATE IN THE EPIDERMIS OF DROSOPHILA
THE CHOICE OF CELL FATE IN THE EPIDERMIS OF DROSOPHILA
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DOI：
10.1016/0092-8674(91)90263-x
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发表时间：
1991-03-22
期刊：
影响因子：
64.5
通讯作者：
SIMPSON, P
中科院分区：
文献类型：
--
作者：
HEITZLER, P;SIMPSON, P
在果蝇中，神经前体以间隔模式形成，中间有表皮细胞分隔。神经系和表皮系的分离依赖于细胞间的相互作用。这种细胞通讯的失败，如突变的Notch (N)、Delta和shaggy，导致大多数或所有细胞变成神经细胞。N和shaggy突变的细胞，而不是Delta突变的细胞，在嵌合中与野生型细胞相邻时，自主地采用神经命运。此外，如果相邻细胞表达的N活性水平低于自身，野生型细胞会选择表皮细胞的命运，而如果相邻细胞表达的N活性水平高于自身，则会产生神经前体。这表明细胞之间存在竞争，N蛋白是细胞在不同命运之间进行选择的机制所必需的。它还表明，N作为一个受体，从神经前体发出的抑制信号。
In Drosophila, neural precursors are formed in a spaced pattern separated by intervening epidermal cells. Segregation of neural and epidermal lineages relies on cellular interactions. Failure of this cell communication, as in the mutants Notch (N), Delta, and shaggy, results in most or all of the cells becoming neural. Cells mutant for N and shaggy, but not Delta, autonomously adopt the neural fate when adjacent to wild-type cells in mosaics. Furthermore, wild-type cells adopt the epidermal fate if adjacent cells express a lower level of N activity than themselves, but produce neural precursors if adjacent cells express a higher level of N activity. This shows that there is competition between the cells and that the N protein is required for the mechanism whereby the cells choose between alternative fates. It also suggests that N acts as a receptor for an inhibitory signal emanating from the neural precursors.