Intrabdominal fat is related to metabolic risk factors in Hispanic Americans, African Americans and in girls
Intrabdominal fat is related to metabolic risk factors in Hispanic Americans, African Americans and in girls
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DOI：
10.1111/j.1651-2227.2009.01474.x
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发表时间：
2009-12-01
期刊：
影响因子：
3.8
通讯作者：
Fernandez, J. R.
中科院分区：
文献类型：
--
作者：
Casazza, K.;Dulin-Keita, A.;Fernandez, J. R.
目的：本研究旨在测试个体脂肪库与心脏代谢结果的关联，该关联是否因库而异，以及该关联是否因青春期早期儿童的种族/族裔或性别而异。方法：320 名 7-12 岁的儿童（53% 男性）自我认定为非裔美国人 (AA; n = 114)、欧洲裔美国人 (EA; n = 120) 或西班牙裔美国人 (HA; n = 86) 参加。通过静脉内葡萄糖耐量试验评估胰岛素动态； DXA 身体成分；用CT观察脂肪分布情况。结果：每个仓库中AA的脂肪最少，HA最多。脂肪积累会对心脏代谢结果产生负面影响，与种族/民族或性别无关。 AA 和雌性的生殖能力更加成熟。在 AA 和 HA 中，每种肥胖指标都会影响胰岛素敏感性指数 (S-I)，而腹内脂肪组织 (IAAT) 对 EA 中的 S-I 没有贡献。仅 AA 中 IAAT 与血压呈正相关。在女性中，肥胖对心脏代谢结果产生不利影响，例如总脂肪量、IAAT 和/或 SAAT 与 S-I 呈负相关，与血压和空腹胰岛素呈正相关。结论：IAAT 与西班牙裔美国人、非裔美国人和女孩的代谢危险因素具有独特的相关性，表明 IAAT 不良反应的阈值较低，或者这些群体中的 IAAT 代谢存在差异。
Aim:This study aimed to test the association of individual adipose depots on cardiometabolic outcomes, whether the association varied by depot and if the associations differed by race/ethnicity or gender in early pubertal children.Methods:Three hundred and twenty children (53% male) aged 7-12 years self-identified as African American (AA; n = 114), European American (EA; n = 120) or Hispanic American (HA; n = 86) participated. Insulin dynamics were assessed by intravenous glucose tolerance test; body composition with DXA; fat distribution with CT.Results:AA had the least fat in each depot and HA had the most. Fat accumulation negatively impacted cardiometabolic outcomes independent of race/ethnicity or gender. AA and females were reproductively more mature. In AA and HA, each measure of adiposity influenced the insulin sensitivity index (S-I), whereas intra-abdominal adipose tissue (IAAT) did not contribute to S-I in EA. IAAT was positively associated with blood pressure in AA only. In females, adiposity adversely influenced cardiometabolic outcomes such that total fat mass, IAAT and/or SAAT was inversely associated with S-I, and positively associated with blood pressure and fasting insulin.Conclusion:IAAT is uniquely related to metabolic risk factors in Hispanic Americans, African Americans and girls, suggesting that either the threshold for adverse effects of IAAT is lower, or the IAAT metabolism differs in these groups.